Evidence map›Paper›PMID 41041867›Full record

ArticleMolecular medicine reports2025

Regulation of nuclear transport of the transcriptional factor REST improves axon regeneration in peripheral nerves.

Takamaru Suzuki, Kiyohito Naito, Daisuke Kubota, Yuji Ueno, Takako Negishi-Koga, Yasuhiro Yamamoto, So Kawakita, Norizumi Imazu, Kenjiro Kawamura, Nobutaka Hattori and 1 more

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Article in Molecular medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Takamaru SuzukiDepartment of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, Tokyo 113‑8421, Japan.
Kiyohito NaitoDepartment of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, Tokyo 113‑8421, Japan.
Daisuke KubotaDepartment of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, Tokyo 113‑8421, Japan.
Yuji UenoDepartment of Neurology, Graduate School of Medical Sciences, University of Yamanashi, Chuo‑shi, Yamanashi 409‑3898, Japan.
Takako Negishi-KogaDepartment of Orthopaedics, Juntendo University Faculty of Medicine, Tokyo 113‑8421, Japan.
Yasuhiro YamamotoDepartment of Orthopaedics, Juntendo University Faculty of Medicine, Tokyo 113‑8421, Japan.
So KawakitaDepartment of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, Tokyo 113‑8421, Japan.
Norizumi ImazuDepartment of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, Tokyo 113‑8421, Japan.
Kenjiro KawamuraDepartment of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, Tokyo 113‑8421, Japan.
Nobutaka HattoriDepartment of Neurology, Juntendo University Faculty of Medicine, Tokyo 113‑8421, Japan.
Muneaki IshijimaDepartment of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, Tokyo 113‑8421, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The expression of repressor element 1 silencing transcription factor (REST) in peripheral nerves increases with age, which leads to a decline in axon regeneration. However, the detailed mechanisms behind the decline in axon regeneration with age remain to be elucidated. The present study investigated the mechanism of nuclear transport of REST using hydrogen (H

Indexed as

AxonsCell NucleusNerve RegenerationPeripheral NervesRepressor ProteinsActive Transport, Cell NucleusAnimalsGAP-43 ProteinMaleMiceNIH 3T3 CellsRE1-Silencing Transcription FactorGAP-43 ProteinRE1-Silencing Transcription FactorRepressor Proteinsagingaxon regenerationhydrogennuclear transportrepressor element 1 silencing transcription factor

Identifiers

PMID41041867
PMCPMC12522182

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.