Evidence map›Paper›PMID 41041863›Full record

ArticleOncology reports2025

miR‑100‑5p and miR‑203a‑3p suppress esophageal squamous cell carcinoma progression by targeting FKBP5.

Hiroto Tanaka, Suguru Maruyama, Katsutoshi Shoda, Yoshihiko Kawaguchi, Yudai Higuchi, Takaomi Ozawa, Takashi Nakayama, Ryo Saito, Wataru Izumo, Koichi Takiguchi and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hiroto TanakaDepartment of Digestive Surgery, University of Yamanashi, Chuo, Yamanashi 409‑3898, Japan.
Suguru MaruyamaDepartment of Digestive Surgery, University of Yamanashi, Chuo, Yamanashi 409‑3898, Japan.
Katsutoshi ShodaDepartment of Digestive Surgery, University of Yamanashi, Chuo, Yamanashi 409‑3898, Japan.
Yoshihiko KawaguchiDepartment of Digestive Surgery, University of Yamanashi, Chuo, Yamanashi 409‑3898, Japan.
Yudai HiguchiDepartment of Digestive Surgery, University of Yamanashi, Chuo, Yamanashi 409‑3898, Japan.
Takaomi OzawaDepartment of Digestive Surgery, University of Yamanashi, Chuo, Yamanashi 409‑3898, Japan.
Takashi NakayamaDepartment of Digestive Surgery, University of Yamanashi, Chuo, Yamanashi 409‑3898, Japan.
Ryo SaitoDepartment of Digestive Surgery, University of Yamanashi, Chuo, Yamanashi 409‑3898, Japan.
Wataru IzumoDepartment of Digestive Surgery, University of Yamanashi, Chuo, Yamanashi 409‑3898, Japan.
Koichi TakiguchiDepartment of Digestive Surgery, University of Yamanashi, Chuo, Yamanashi 409‑3898, Japan.
Kensuke ShiraishiDepartment of Digestive Surgery, University of Yamanashi, Chuo, Yamanashi 409‑3898, Japan.
Shinji FuruyaDepartment of Digestive Surgery, University of Yamanashi, Chuo, Yamanashi 409‑3898, Japan.
Hidetake AmemiyaDepartment of Digestive Surgery, University of Yamanashi, Chuo, Yamanashi 409‑3898, Japan.
Hiromichi KawaidaDepartment of Digestive Surgery, University of Yamanashi, Chuo, Yamanashi 409‑3898, Japan.
Daisuke IchikawaDepartment of Digestive Surgery, University of Yamanashi, Chuo, Yamanashi 409‑3898, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poorly differentiated cancers, including esophageal squamous cell carcinoma (ESCC), exhibit higher malignant potential and worse prognoses than well‑differentiated types. The present study aimed to identify microRNAs (miRNAs or miRs) involved in ESCC progression and their target mRNAs, focusing on tumor differentiation. miRNA candidates were selected using a miRNA array‑based approach and GEO datasets, comparing expression levels between poorly and non‑poorly differentiated ESCC. Clinical samples (n=61) and cell lines were analyzed to determine the significance and function of the selected miRNAs and their target mRNA. miR‑100‑5p and miR‑203a‑3p were significantly downregulated in poorly differentiated ESCC, with lower expression strongly associated with poorer overall survival (OS) (miR‑100‑5p: P=0.02; miR‑203a‑3p: P=0.05) and relapse‑free survival (RFS) (miR‑100‑5p: P=0.04; miR‑203a‑3p: P=0.12). Overexpression of these miRNAs suppressed cell migration and invasion.

Indexed as

Esophageal NeoplasmsEsophageal Squamous Cell CarcinomaMicroRNAsTacrolimus Binding ProteinsAdultAgedBiomarkers, TumorCell Line, TumorCell MovementCell ProliferationDisease ProgressionDown-RegulationFemaleGene Expression Regulation, NeoplasticHumansMaleBiomarkers, TumorMicroRNAsMIRN203 microRNA, humanTacrolimus Binding Protein 5Tacrolimus Binding ProteinsESCCesophageal cancerFKBP5miR‑100‑5pmiR‑203a‑3ppoor differentiation

Identifiers

PMID41041863
PMCPMC12521887

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.