Evidence map›Paper›PMID 41041724›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2025

Prediction of Pathological Subthalamic Nucleus Beta Burst Occurrence in Parkinson's Disease.

Bahman Abdi-Sargezeh, Sepehr Shirani, Abhinav Sharma, Tao Liu, Alexander Green, Harith Akram, Ludvic Zrinzo, Patricia Limousin, Tom Foltynie, Timothy Denison and 5 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation.Movement disorders : official journal of the Movement Disorder Society · 2026
    Review
  3. Article
  4. Pre-Beta Burst Dynamics in Parkinson's Disease: Distinguishing Signal from Artifact.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Bahman Abdi-SargezehMRC Brain Network Dynamics Unit, University of Oxford, Oxford, UK.
Sepehr ShiraniMental Health Neuroscience Department, Division of Psychiatry and Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, London, UK.
Abhinav SharmaMRC Brain Network Dynamics Unit, University of Oxford, Oxford, UK.
Tao LiuMRC Brain Network Dynamics Unit, University of Oxford, Oxford, UK.
Alexander GreenNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Harith AkramDepartment of Clinical and Movement Neurosciences, University College London, London, UK.
Ludvic ZrinzoDepartment of Clinical and Movement Neurosciences, University College London, London, UK.ORCID https://orcid.org/0000-0002-6013-4946
Patricia LimousinDepartment of Clinical and Movement Neurosciences, University College London, London, UK.
Tom FoltynieDepartment of Clinical and Movement Neurosciences, University College London, London, UK.ORCID https://orcid.org/0000-0003-0752-1813
Timothy DenisonMRC Brain Network Dynamics Unit, University of Oxford, Oxford, UK.
Huiling TanMRC Brain Network Dynamics Unit, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0001-8038-3029
Vladimir LitvakWellcome Centre for Human Neuroimaging, University College London, London, UK.
Simon LittleDepartment of Neurology Surgery, University of California San Francisco, San Francisco, USA.
Philip A StarrDepartment of Neurosurgery, University of California San Francisco, San Francisco, USA.
Ashwini OswalMRC Brain Network Dynamics Unit, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-0152-9294

Funding

China Scholarship CouncilJon Moulton Charity TrustMedical Research Council MC_UU_00003/2Medical Research Council MR/P012272/1Medical Research Council MR/V00655X/1Medical Research Council MR/W024810/1NIHR Oxford Biomedical Research CentreOxford Hospitals CharityRosetrees TrustUCLH Biomedical Research CentreWellcome TrustWellcome Trust 203147/Z/16/Z
6 · The paper itself

Abstract

backgroundThe corticobasal ganglia network in Parkinson's disease (PD) is characterized by the occurrence of transient episodes of exaggerated beta frequency oscillatory synchrony, known as bursts. Although it is known that bursts of prolonged duration associate closely with motor impairments, the mechanisms leading to burst initiation remain poorly understood. Related to this, current adaptive deep brain stimulation (DBS) approaches reactively deliver stimulation following burst onset but cannot stimulate proactively to prevent bursts from occurring. The discovery of predictive biomarkers could allow for proactive stimulation, thereby offering potential for improvements in therapeutic efficacy.

objectivesWe aimed to address this issue, by using deep neural networks to discover features of basal ganglia activity that reliably precede beta burst onset.

methodsWe developed a deep learning model to predict burst onset from subthalamic nucleus (STN) activity recordings in PD patients. Our model provides patient-specific predictions in two independent datasets of STN recordings, including prolonged-duration recordings from sensing-enabled DBS devices during naturalistic behaviors.

resultsThe occurrence of STN beta bursts can be reliably predicted up to 100 ms prior to onset. Importantly, our results reveal that a dip in the beta amplitude-which is likely to be indicative of a phase reset of oscillatory populations occurring between 80 and 100 ms prior to burst onset-is a predictive biomarker for burst occurrence.

conclusionsThese findings demonstrate proof-of-principle for the feasibility of beta burst prediction and inform the future development of intelligent DBS approaches with the capability of proactive stimulation to prevent beta burst occurrence. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Indexed as

Basal GangliaBeta RhythmDeep Brain StimulationDeep LearningParkinson DiseaseSubthalamic NucleusAgedFemaleHumansMaleMiddle Agedbeta burst predictiondeep brain stimulationParkinson's diseasesubthalamic nucleus

Identifiers

PMID41041724
PMCPMC12710186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.