Evidence map›Paper›PMID 41041715›Full record

ArticleeLife2025

Optogenetic stimulation of single ganglion cells in the living primate fovea.

Peter J Murphy, Juliette E McGregor, Zhengyang Xu, Qiang Yang, William Merigan, David R Williams

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Peter J MurphyThe Institute of Optics, University of Rochester, Rochester, United States.ORCID https://orcid.org/0000-0002-9885-7779
Juliette E McGregorCenter for Visual Science, University of Rochester, Rochester, United States.ORCID https://orcid.org/0000-0002-8046-028X
Zhengyang XuThe Institute of Optics, University of Rochester, Rochester, United States.ORCID https://orcid.org/0009-0004-9355-8405
Qiang YangCenter for Visual Science, University of Rochester, Rochester, United States.
William MeriganThe Institute of Optics, University of Rochester, Rochester, United States.ORCID https://orcid.org/0009-0005-9411-6120
David R WilliamsThe Institute of Optics, University of Rochester, Rochester, United States.

Funding

VISUAL SCIENCE RESEARCH CTR SUPPORTP30EY001319 · NEI · UNIVERSITY OF ROCHESTER · PI Susana Marcos · 1985 to 2026
$17.5M
High Resolution Mapping of Foveal Ganglion Cell Receptive Fields in the Living Primate EyeR01EY031467 · NEI · UNIVERSITY OF ROCHESTER · PI DAVID R WILLIAMS · 2021 to 2026
$3.5M
NEI NIH HHS P30 EY001319NEI NIH HHS P30EY001319NEI NIH HHS R01 EY031467NEI NIH HHS R01EY031467United States Air Force Office of Scientific Research FA9550-22-1-0167
6 · The paper itself

Abstract

Though the responses of the rich variety of retinal ganglion cells (RGCs) reflect the totality of visual processing in the retina and provide the sole conduit for those processed responses to the brain, we have much to learn about how the brain uses these signals to guide behavior. An impediment to developing a comprehensive understanding of the role of retinal circuits in behavior is the paucity of causal studies in the intact primate visual system. Here, we demonstrate the ability to optogenetically activate individual RGCs with flashes of light focused on single RGC somas in vivo, with no evidence for activation of neighboring cells. The ability to selectively activate specific cells is the first step toward causal experiments that directly link retinal circuits to visual experience and behavior.

Indexed as

Fovea CentralisOptogeneticsRetinal Ganglion CellsAnimalsMacaca mulattaPhotic Stimulationcrab-eating macaquecynomolgus macaqueMacaca fascicularisneuroscience

Identifiers

PMID41041715
PMCPMC12494377

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.