Evidence map›Paper›PMID 41041706›Full record

ArticleMagnetic resonance in medicine2026

Robust Extrapolated Semi-Solid Magnetization Transfer Reference Fitting for Quantitative Amide Proton Transfer Imaging at 3 T: Application to Patients With Mild Cognitive Impairment and Mild Dementia.

Jingpu Wu, Zongpai Zhang, Isabel M Rios Pulgar, Shanshan Jiang, Puyang Wang, Keyi Chai, Arvind P Pathak, Kenichi Oishi, Yuguo Li, Jee Bang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jingpu WuDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Zongpai ZhangDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Isabel M Rios PulgarDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Shanshan JiangDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Puyang WangDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Keyi ChaiDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Arvind P PathakDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Kenichi OishiDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Yuguo LiDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Jee BangDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Abhay MoghekarDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Carrie WagandtDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Gwenn S SmithDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Chiadi U OnyikeDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Gregory M PontoneDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Arnold BakkerDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Jinyuan ZhouDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-6684-7920

Funding

Longitudinal Molecular Imaging of Neuropathology and Serotonin in Mild Cognitive ImpairmentR01AG059390 · NIA · JOHNS HOPKINS UNIVERSITY · PI SMITH, GWENN S · 2018 to 2022
$4.8M
Developing Protein-based MRI Biomarkers for Alzheimer's DiseaseR01AG069179 · NIA · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2020 to 2024
$3.3M
Integrating circulating tumor DNA assay and protein-based MRI to accurately monitor glioma therapyR01CA276221 · NCI · JOHNS HOPKINS UNIVERSITY · PI CHETAN BETTEGOWDA, Shanshan Jiang · 2023 to 2026
$2.7M
Quantitative CEST MRI for GBM Early Response Prediction and Biopsy GuidanceR37CA248077 · NCI · JOHNS HOPKINS UNIVERSITY · PI Shanshan Jiang · 2021 to 2026
$2.2M
Research Education Program for Residents and Fellows in NeurologyUE5NS065729 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CHETAN BETTEGOWDA, Argye E. Hillis · 2025 to 2026
$606k
NCI NIH HHS R01 CA276221NCI NIH HHS R37 CA248077NIA NIH HHS R01 AG059390NIA NIH HHS R01 AG069179NIH HHS R01AG069179NIH HHS R01CA276221NIH HHS R37CA248077NINDS NIH HHS UE5 NS065729
6 · The paper itself

Abstract

purposeTo refine the utility of the extrapolated semi-solid magnetization transfer reference (EMR) method for amide proton transfer (APT) quantification.

methodsTwelve patients (7 mild cognitive impairment and 5 mild dementia; 66.3 ± 8.7 years) and 13 age-matched, cognitively normal volunteers (68.6 ± 8.0 years), as well as a 10% cross-linked bovine-serum-albumin phantom, were scanned at 3 T. A two-step, coarse-to-fine EMR fitting approach was developed, and a bias term was introduced to compensate for the discrepancy between the ideal model and practical data. The fitted model parameters and calculated APT

resultsPhantom results confirmed that the proposed EMR method had lower fitting errors and closer-to-zero APT

conclusionThe proposed EMR method enabled more accurate quantification of APT signals and could potentially facilitate the use of APT imaging in the diagnosis and staging of Alzheimer's disease and related dementias.

Indexed as

AmidesCognitive DysfunctionDementiaImage Processing, Computer-AssistedMagnetic Resonance ImagingAgedAged, 80 and overAlgorithmsBrainFemaleHumansMaleMiddle AgedPhantoms, ImagingProtonsAmidesProtonsAlzheimer's diseaseamide proton transfer imagingEMR fittingmild cognitive impairment

Identifiers

PMID41041706
PMCPMC12682360

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.