Evidence map›Paper›PMID 41041688›Full record

ArticleANZ journal of surgery2025

A Pilot Study of Porcine Acellular Bladder Matrix Filling in the Treatment of Anal Fistulas: A Single-Center Cohort Study.

Xiang Ma, Weisong Xue, Zuolin Zhou, Qiong He, Feng Yang, Ningchao Du, Jun Sun, Huiwen Ning, NiNi Liu, Ying Luo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ANZ journal of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiang MaDepartment of Colorectal Surgery, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen University, Shenzhen, China.ORCID 0009-0008-2150-7405
Weisong XueDepartment of Colorectal Surgery, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen University, Shenzhen, China.
Zuolin ZhouDepartment of Colorectal Surgery, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen University, Shenzhen, China.
Qiong HeDepartment of Colorectal Surgery, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen University, Shenzhen, China.
Feng YangDepartment of Colorectal Surgery, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen University, Shenzhen, China.
Ningchao DuDepartment of Colorectal Surgery, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen University, Shenzhen, China.
Jun SunDepartment of Colorectal Surgery, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen University, Shenzhen, China.
Huiwen NingDepartment of Colorectal Surgery, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen University, Shenzhen, China.
NiNi LiuDepartment of Colorectal Surgery, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen University, Shenzhen, China.
Ying LuoDepartment of Colorectal Surgery, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen University, Shenzhen, China.
Jian CaiDepartment of Colorectal Surgery, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen University, Shenzhen, China.

Funding

Shenzhen Second People's Hospital Clinical Research Fund of Shenzhen High-level Hospital Construction Project 20243357016Shenzhen Second People's Hospital Clinical Research Fund of Shenzhen High-level Hospital Construction Project 2025WQJJ02
6 · The paper itself

Abstract

objectiveThis study aimed to preliminarily assess the effectiveness of a novel biomaterial, porcine acellular bladder matrix (PABM), in filling fistula tracts. SUMMARY OF BACKGROUND DATA: Anal fistula plugs (AFPs) made from biomaterials are designed to fill fistulas, promote tissue healing, and prevent anal sphincter damage caused by conventional surgeries.

methodsThis single-center cross-sectional study evaluated PABM-AFP treatment for anal fistulas between May 2023 and May 2024. Twenty-eight patients diagnosed with anal fistulas underwent PABM-AFP filling, with follow-up conducted for 6-12 months postoperatively.

resultsThe overall success rate was 89.3%, with an efficacy rate of 90.6% for all treated fistulas. Of the three patients who experienced treatment failure, two recovered after receiving thread-ligating treatment, and the remaining patient who had Crohn's disease experienced partial healing. The mean healing time was 5 weeks, and the average follow-up duration was 7 months. No adverse complications were reported.

conclusionsPABM-AFP is a promising, safe, and effective treatment option for anal fistulas. This study provides valuable preliminary data to support the clinical use of PABM-AFP.

Indexed as

Biocompatible MaterialsRectal FistulaUrinary BladderAdultAgedAnimalsCohort StudiesCross-Sectional StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedPilot ProjectsSwineTreatment OutcomeBiocompatible Materialsanal sphincterbiocompatible materialsrectal fistulatissue engineering

Identifiers

PMID41041688
PMCPMC12717480

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.