ArticleFrontiers in neurology2025
Serum interleukin-40 increases in anti-AchR antibody-positive myasthenia gravis and correlates with disease activity.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Interleukin-40 (IL-40), as an immune regulatory factor discovered in recent years, mainly plays a role in B-cell-related immune responses and is involved in the pathological processes of various inflammatory diseases, autoimmune disorders, and infectious diseases. However, its role in myasthenia gravis (MG) has rarely been reported. Methods: We used enzyme-linked immunosorbent assay (ELISA) to measure the serum IL-40 levels in 58 MG patients and 55 healthy controls, and conducted a detailed analysis of the clinical data. Results: The serum IL-40 level in MG patients was significantly higher than that in healthy controls ( Conclusion: The serum IL-40 level in MG patients is elevated and is correlated with the severity of the disease. High levels of IL-40 may serve as a specific indicator for monitoring disease activity, which supports its potential as a non-invasive biomarker for disease monitoring.
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