ArticleFrontiers in neurology2025
Size of affected vessels in primary angiitis of the CNS: associations with clinical features, medical management and functional outcomes.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Primary angiitis of the central nervous system (PACNS) presents with heterogeneous clinical manifestations. Since implications of specific patterns of vessel size involvement are not well elucidated, this study aimed to investigate individual disease courses by involved vessel calibers and systematically assess clinical outcomes, relapses, and demographic data. Methods: This single-center retrospective study (January 2010-April 2022) included 105 cerebral vasculitis patients. PACNS cases ( Results: Among 49 PACNS patients (53.1% female, mean age 46.8 years), cardiovascular risk factors, specifically body weight ( Conclusion: Despite a limited sample size due to the rarity of the disease, our study highlights vessel size as a key factor in PACNS heterogeneity, associating small vessel involvement with worse functional outcomes, greater imaging progression, and distinct treatment patterns. These findings underscore the importance of vessel size in understanding PACNS pathophysiology and guiding management.
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