SynthesisFrontiers in neurology2025
Dopamine in Tourette syndrome: a 30-year bibliometric analysis of hotspot evolution.
Synthesis in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Computational Identification of Blood-Brain Barrier-Permeant Microbiome Metabolites with Binding Affinity to Neurotransmitter Receptors in Neurodevelopmental Disorders.Molecules (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Tourette syndrome (TS), a neurodevelopmental disorder, requires attention to the physical and psychological impacts of tics and associated comorbidities. Researchers are making efforts to clarify the pathophysiology of TS and develop effective treatments amidst its rising global prevalence. This study aimed to retrieve publications discussing TS in the context of the dopaminergic system from 1994 to 2023, summarize previous research, and analyze the general information and hotspots to provide references for future research and clinical applications. Methods: Literature was filtered from the Web of Science Core Collection. Excel, CiteSpace, VOSviewer, and Scimago Graphica were used to analyze and visualize the results. Results: A total of 482 related publications were included in the study. The United States has consistently led in research output, and Yale University demonstrates excellence in workload, impact, and collaboration. Harvey S. Singer has the highest number of publications. The hotspots include comorbidities, dopaminergic Components, candidate genes, and deep brain stimulation. Discussion: The analysis reveals that the understanding of TS is gradually evolving towards neuronal and genetic mechanisms. Concurrently, deep brain stimulation is being investigated as a treatment for refractory TS. These findings suggest a need for more in-depth research to produce higher-level evidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.