Evidence map›Paper›PMID 41041663›Full record

ArticleFrontiers in cell and developmental biology2025

Oxygen concentration modulates HDAC1-Mediated regulation of osteogenic signaling pathways in dental pulp cells.

Ci Song, Ping Li, Lin Lin, Ge Cao, Zhao Liu, Fei Liu, Ling Peng, Jingxing Dai, Buling Wu, Ting Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ci Song *Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ping Li *Department of Stomatology, The Eighth Medical Center of PLA General Hospital, Beijing, China.
Lin Lin *Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ge Cao *Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zhao LiuCollege of Stomatology, Southern Medical University, Guangzhou, China.
Fei LiuCollege of Stomatology, Southern Medical University, Guangzhou, China.
Ling PengCollege of Stomatology, Southern Medical University, Guangzhou, China.
Jingxing DaiGuangdong Provincial Key Laboratory of Digital Medicine and Biomechanics & Guangdong Engineering Research Center for Translation of Medical 3D Printing Application & National Virtual & Reality Experimental Education Center for Medical Morphology (Southern Medical University) & National Experimental Education Demonstration Center for Basic Medical Sciences (Southern Medical University) & National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Buling WuDepartment of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ting ChenDepartment of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Dental pulp regeneration represents a critical frontier in translational dentistry, with dental pulp stem cells (DPSCs) demonstrating exceptional reparative potential through their multipotent differentiation capacity. While oxygen tension is known to influence cellular physiology, its regulatory mechanisms on DPSC osteo/odontogenic differentiation remain poorly understood. Methods: We established physiologically relevant oxygen gradients (3%, 5%, 21% O Results: Moderate hypoxia (5% O Conclusion: Our findings establish an oxygen-sensitive HDAC/HIF-1α regulatory axis governing DPSC fate determination. The biphasic response to hypoxia gradients suggests microenvironmental optimization strategies could enhance pulp regenerative outcomes. These insights provide mechanistic foundations for developing HDAC-targeted approaches in endodontic regeneration.

Indexed as

dental pulp stem cellsepigenetic regulationhypoxic microenvironmentosteogenic differentiationregenerative endodontics

Identifiers

PMID41041663
PMCPMC12485506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.