Evidence map›Paper›PMID 41041547›Full record

ArticleResearch square2025

Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T-cell-mediated cytotoxicity.

Syed Ali Raza, Yoshimi Enose-Akahata, Anna Blazier, Lauren M Guerra, Erin S Beck, María I Gaítan, Nyater Ngouth, Jefte M Drijvers, Eric B Dammer, Devan Moodley and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Syed Ali RazaTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0003-4782-2100
Yoshimi Enose-AkahataViral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-7102-9703
Anna BlazierSanofi, Cambridge, MA, USA.
Lauren M GuerraTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Erin S BeckTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0001-7839-7958
María I GaítanTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0003-4455-5641
Nyater NgouthViral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Jefte M DrijversAbata Therapeutics, Watertown, MA, USA.
Eric B DammerDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.ORCID https://orcid.org/0000-0003-2947-7606
Devan MoodleyAbata Therapeutics, Watertown, MA, USA.
Kory R JohnsonBioinformatics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.ORCID https://orcid.org/0000-0002-6693-3378
Martina AbsintaDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.ORCID https://orcid.org/0000-0003-0276-383X
Valeria RamagliaKrembil Research Institute, Toronto, ON, Canada.
Jennifer GommermanUniversity of Toronto, ON, Canada.ORCID https://orcid.org/0000-0003-4576-6168
Timothy J TurnerSanofi, Cambridge, MA, USA.
Richard M RansohoffThird Rock Ventures, Boston, MA, USA.
Steven JacobsonViral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Dimitry OfengeimSanofi, Cambridge, MA, USA.
Ellen Cahir-McFarlandAbata Therapeutics, Watertown, MA, USA.
Daniel S ReichTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-2628-4334

Funding

Multimodal MRI in Multiple SclerosisZIANS003119 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI REICH, DANIEL · 2010 to 2025
$53.4M
Intramural NIH HHS ZIA NS003119
6 · The paper itself

Abstract

Chronic neuroinflammation and neurodegeneration are critical but unresolved drivers of disability accumulation in progressive multiple sclerosis (MS). Chronic active white matter lesions, identifiable radiologically as paramagnetic rim lesions (PRL), indicate progression-relevant chronic neuroinflammation. Using single-cell transcriptomics (scRNAseq) and T-cell receptor sequencing (scTCR-seq), we profiled cerebrospinal fluid (CSF) and blood immune cells of 34 radiologically characterized adults with MS (17 untreated, 6 treated with B-cell-depletion) and 5 healthy controls. Coupled with proteomics, we found PRL-associated enrichment of interferon (IFN) signaling and upregulation of TCR signaling in CSF and blood. This was accompanied by clonal expansion of CD8

Identifiers

PMID41041547
PMCPMC12486096

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.