ArticleResearch square2025
Ifi27l2a acts as a cytokine that promotes a pro-inflammatory phenotype in microglia and enhances neuroinflammation.
Sodam Kim, Haven Burrous, Elisabeth Harmon, Lauren Vance, Ting Wu, Alexander Andersohn, Andrea Doan, Darby Wolocko, Zachary Wise, Yuki Kitamura and 7 more
Abstract readPreprint
In one paragraphArticle in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
17 authors.
Sodam KimThe University of Texas Health Science Center at Houston.
Haven BurrousThe University of Texas Health Science Center at Houston.
Elisabeth HarmonThe University of Texas Health Science Center at Houston.
Lauren VanceThe University of Texas Health Science Center at Houston.
Ting WuThe University of Texas Health Science Center at Houston.
Alexander AndersohnThe University of Texas Health Science Center at Houston.
Andrea DoanThe University of Texas Health Science Center at Houston.
Darby WolockoThe University of Texas Health Science Center at Houston.
Zachary WiseThe University of Texas Health Science Center at Houston.
Joo Eun JungThe University of Texas Health Science Center at Houston.
Gabriela ColpoThe University of Texas Health Science Center at Houston.
Lucy CoutureThe University of Texas Health Science Center at Houston.
Frank BlixtThe University of Texas Health Science Center at Houston.
Louise McCulloughThe University of Texas Health Science Center at Houston.
Sean MarrelliThe University of Texas Health Science Center at Houston.
Gab Seok KimThe University of Texas Health Science Center at Houston.
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI PAVAN REDDY · 2007 to 2026
$73.9MModifying endothelial Piezo 1 function to improve brain perfusion in AD/ADRDR01AG081942 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Sean P Marrelli · 2023 to 2026
$2.7MIdentify the DNA Adduct and Associated Metabolic Alterations in Bladder Cancer of SmokersR01CA216426 · NCI · BAYLOR COLLEGE OF MEDICINE · PI EL-ZEIN, RANDA A, PUTLURI, NAGIREDDY · 2018 to 2022
$2.0MIfi27l2a as a therapeutic target for strokeR01NS133324 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GAB SEOK KIM · 2023 to 2026
$1.9MRacial Disparity in Bladder Cancer and Identification of Altered Metabolism in African American Compare to European Bladder CancerR01CA220297 · NCI · BAYLOR COLLEGE OF MEDICINE · PI PUTLURI, NAGIREDDY · 2017 to 2021
$1.8MDefining the role of endothelial Piezo1, a mechanosensitive ion channel, in providing resilience to vascular contributions to cognitive impairment and dementia (VCID)R56NS120709 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MARRELLI, SEAN P · 2021 to 2021
$620kEnhancing microglia-dependent plaque clearance in the Alzheimer disease brain by targeting Ifi27l2a expressionR21AG072488 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KIM, GAB SEOK · 2021 to 2021
$429kNCI NIH HHS P30 CA125123NCI NIH HHS R01 CA216426NCI NIH HHS R01 CA220297NIA NIH HHS R01 AG081942NIA NIH HHS R21 AG072488NINDS NIH HHS R01 NS133324NINDS NIH HHS R56 NS120709
6 · The paper itselfAbstract
Interferon alpha-inducible protein 27 like 2A (
Identifiers
PMID41041541
PMCPMC12486113
What OpenQuestion holds
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