Evidence map›Paper›PMID 41041537›Full record

ArticleResearch square2025

RPS19 and RPL5 Haploinsufficient Models Reveal Divergent Ribosomal Subunit Controls of Fetal Hematopoiesis.

Lionel Blanc, Yuefeng Tang, Te Ling, Rashid Mehmood, Alexis Bertrand, Julien Papoin, Mushran Khan, Riaz Rao, Jianing Xu, Vincent Schulz and 17 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Lionel BlancFeinstein Institute For Medical Research.ORCID 0000-0002-0185-6260
Yuefeng TangNorthwell.
Te LingSt. Jude Children's Research Hospital.
Rashid MehmoodDepartment of Hematology, St. Jude Children's Research Hospital.
Alexis BertrandNorthwell.
Julien PapoinNorthwell.
Mushran KhanNorthwell.
Riaz RaoNorthwell.
Jianing XuFudan University.
Vincent SchulzYale University.
James PalisUniversity of Rochester Medical Center.ORCID 0000-0001-7324-1049
Laurie SteinerUniversity of Rochester.
Betsy BarnesNorthwell.
YongRui ZouNorthwell.
Philippe MarambaudFeinstein Institute for Medical Research.ORCID 0000-0002-8983-1497
Robert SignerUniversity of San Diego.
Irene RobertsUniversity of Oxford.
Deena IskanderImperial College London.ORCID 0000-0002-1278-3888
Leonard ZonBoston Children's Hospital.ORCID 0000-0003-0860-926X
Senthil BhoopalanSt Jude.
Mitchell WeissSt. Jude Children's Research Hospital.ORCID 0000-0003-2460-3036
Jeffrey LiptonNorthwell.
Patrick GallagherNationwide.
Narla MohandasNew York Blood Center.ORCID 0000-0003-2271-5296
Naomi TaylorInstitut de Génétique Moléculaire de Montpellier, CNRS.ORCID 0000-0002-2459-4558
Sebastien DurandCRCL.
John CrispinoSt Jude Children's Research Hospital.ORCID 0000-0002-8182-8306

Funding

Cellular and Molecular Control of Normal and Disordered ErythropoiesisR35HL171168 · NHLBI · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI Lionel Blanc · 2024 to 2026
$2.6M
Functional characterization of the endothelial cell niche for hematopoietic stem cellsR01DK140372 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI LEONARD Ira ZON · 2024 to 2026
$2.1M
The role of the N-terminus of GATA1 in erythropoiesisR01DK141059 · NIDDK · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI John D Crispino · 2024 to 2026
$1.9M
Stress Granules in Red Blood Cell DevelopmentR01DK143991 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI LEONARD Ira ZON · 2025 to 2026
$1.6M
NHLBI NIH HHS R35 HL171168NIDDK NIH HHS R01 DK140372NIDDK NIH HHS R01 DK141059NIDDK NIH HHS R01 DK143991
6 · The paper itself

Abstract

Diamond Blackfan anemia syndrome (DBAS) is a congenital ribosomopathy caused by haploinsufficiency of ribosomal proteins (RPs), but how RP stoichiometry and activity regulates erythroid development remains enigmatic. Using novel

Identifiers

PMID41041537
PMCPMC12486077

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.