ArticleFrontiers in medicine2025
Differences in the amplitude of dynamic low-frequency fluctuations in primary angle-closure glaucoma are associated with gene-molecular multi-omics.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Primary angle-closure glaucoma (PACG), an incurable ophthalmic disease, is a serious risk to human visual health. Previous studies have demonstrated a strong link between PACG and neuroimaging changes in the brain. This study utilizes dynamic low-frequency fluctuation amplitude (dALFF) with the aim of resolving the potential dynamic alterations in neurological function in PACG and integrating transcriptomics profiles with spatial distribution characteristics of neuromodulatory receptors/transporters to systematically elucidate the underlying neurophysiopathological mechanisms. Methods: We used sliding time windows of 30TR, 50TR and 80TR to calculate dALFF values and performed partial least squares regression (PLS) analysis of t-values after two-sample test of dALFF values under the sliding window of 50 TR against the Allen Human Brain Atlas (AHBA) to screen genes. Enrichment analysis, tissue-specific expression analysis and protein-protein interactions (PPI) network construction were implemented. The t-values were also analyzed for spatial correlation with neurotransmitter receptor/transporter density profiles distributed throughout the brain. Results: The two-sample tests under three sliding windows revealed extensive brain alterations in PACG and each abnormal brain region showed elevation (the Gaussian Random Field method, with significance at the voxel level set at Conclusion: The present study reveals that a wide range of brain regions in PACG patients show significant functional remodeling, elucidating the molecular regulatory network behind this type of pathological alteration.
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