ArticleFrontiers in medicine2025
Global, regional, and national burden of early-onset colorectal cancer attributable to high BMI (1990-2021).
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Trajectory identification of high-risk subgroups after colorectal cancer surgery in patients with minimal residual disease: a single-center longitudinal study.Journal of gastrointestinal oncology · 2026Article
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3 authors.
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Abstract
Objective: This study aimed to assess the global, regional, and national burden of early-onset colorectal cancer (EO-CRC) attributable to high body mass index (BMI) from 1990 to 2021. By examining demographic, geographic, and sex-specific disparities, the goal was to elucidate trends and inform targeted prevention strategies. Methods: We utilized data from the Global Burden of Disease (GBD) 2021 study, applying population-attributable fraction modeling to estimate disability-adjusted life years (DALYs) linked to high BMI (≥25 kg/m Results: Globally, age-standardized DALY rates (ASDRs) for EO-CRC attributable to high BMI increased from 8.07 per 100,000 in 1990 to 10.49 in 2021. The burden was consistently higher and increased more rapidly among males. While high SDI countries experienced stabilization or even decline in rates after 2017, sharp increases were observed in low-middle and low SDI countries. Population growth and epidemiological transitions were the primary contributors to DALY increases. Projections suggest further growth in burden, especially among males and in lower SDI regions. Conclusion: High BMI plays a substantial role in the rising global burden of EO-CRC, with pronounced disparities across regions and sexes. The shifting burden toward low and middle SDI countries, along with accelerating trends among men, highlights the urgent need for sex- and region-specific obesity prevention and early screening strategies to mitigate the growing public health impact of EO-CRC.
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