ArticleInternational journal of clinical pediatric dentistry2025
Evaluation of Efficacy of Advanced Platelet-rich Fibrin in Premolar Extraction Sockets as an Aid to Accelerate Orthodontic Tooth Movement and Wound Healing: A Split-mouth
Article in International journal of clinical pediatric dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims and background: Surgical extraction of premolars is a routine orthodontic procedure for correcting malocclusion, but is often associated with postoperative challenges. Advanced platelet-rich fibrin (A-PRF), a second-generation platelet concentrate rich in growth factors, offers promise as an adjunct to improve healing outcomes. This study aimed to evaluate the impact of A-PRF on clinical outcomes following surgical premolar extraction. Materials and methods: A prospective split-mouth, Results: The study group demonstrated significantly better wound healing (mean score: 2.53) compared to the control group (mean score: 1.08) ( Conclusion: A-PRF application in orthodontic extraction sockets accelerates wound healing and tooth movement by promoting osteoclastic activity and bone remodeling through a sustained release of growth factors such as platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and transforming growth factor beta (TGF-β). Its minimally invasive autologous nature positions A-PRF as a promising adjunct to orthodontic treatment, reducing treatment duration and enhancing patient outcomes. Clinical significance: A-PRF improves post-extraction healing, reducing discomfort and complications in children. It supports bone remodeling, optimizing alignment and shortening treatment during growth phases. A-PRF is autologous, biocompatible, and minimally invasive, ensuring safety and better cooperation. How to cite this article: Mareddy D, Marimallappa TR, Ranghnath MK,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.