ReviewFrontiers in immunology2025
The role of cGAS-STING signaling in the liver and gastrointestinal system: from signaling networks to target intervention.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cyclic guanosine monophosphate-adenylate synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway constitutes a fundamental mechanism through which the host innate immune system identifies cytoplasmic DNA. This pathway triggers a range of immune responses, notably the production of type I interferon (IFN-I), by detecting both exogenous pathogen-derived DNA and endogenous damage-associated DNA. It plays a pivotal role in anti-infective and anti-tumor responses, as well as in the maintenance of tissue homeostasis. Nevertheless, within the liver and gastrointestinal system-an environment persistently subjected to microbial and metabolic stress-the functionality of the cGAS-STING pathway demonstrates considerable complexity and context dependence. This review provides a comprehensive analysis of the molecular structure and activation mechanisms of the cGAS-STING signaling pathway. It systematically examines the variations in the pathway's role across different disease contexts, cell types, and modes of stimulation. Furthermore, it synthesizes the latest therapeutic strategies targeting this pathway, offering a theoretical foundation and advanced insights for the development of more precise interventions for liver and gastrointestinal diseases.
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Registered trials
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