ReviewFrontiers in immunology2025
Regenerative potential of immune cells after traumatic muscle injury.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Prediction of postoperative pulmonary complications in geriatric patients with hip fracture using a nomogram incorporating bedside ultrasonography and clinical parameters.BMC geriatrics · 2026Observational
- Integrating polyphenols and exercise in cancer prevention, treatment, and rehabilitation: cellular and molecular mechanisms linking the injury-recovery-musculoskeletal resilience axis.Frontiers in oncology · 2026Review
- A clinically useful nomogram integrating bedside lung ultrasound and clinical parameters for pulmonary complications after non-thoracic surgery in blunt chest trauma patients.Frontiers in medicine · 2026Article
- Granulocytes and their Involvement in the Foreign Body Response to Biomaterials and Tissue Repair.In vivo (Athens, Greece)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traumatic muscle injury (TMI) causes significant morbidity and socioeconomic burden. Immune cells are central to the subsequent regenerative response, orchestrating dynamic interactions between innate and adaptive immunity. This review systematically summarizes the current understanding of the roles of key immune cells (neutrophils, macrophages, eosinophils, basophils, T lymphocytes, B lymphocytes) in TMI pathophysiology and repair, based on a comprehensive analysis of recent literature. Their intrinsic mechanisms, contributions to tissue regeneration, and therapeutic implications are discussed. Furthermore, we explore therapeutic strategies targeting immune cells, including biomaterials, pharmacologic interventions, cell therapies, and physical modalities. The aim of this review is to provide a consolidated understanding of immune-mediated repair mechanisms in TMI and to identify critical knowledge gaps and future research directions necessary for developing novel immunomodulatory therapies to optimize muscle regeneration and functional recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.