Trial reportFrontiers in immunology2025
Daytime eccentric exercise and its impact on inflammatory markers and antioxidant defenses in physically active young men.
Trial report in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Within-Day Timing of Concurrent Training Affects Inflammation and Body Composition in Young Adults With Obesity.Obesity (Silver Spring, Md.) · 2026Trial
- Skeletal Muscle Redox Signaling in Health and Disease: From Molecular Mechanisms to Therapeutic Exercise Strategies.Antioxidants (Basel, Switzerland) · 2026Review
- Exercise Timing in Sport: Molecular and Physiological Mechanisms Linking Performance, Recovery, and Biological Cost.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The eccentric exercise performed during the day, whether in the morning or evening, may affect hormonal fluctuations and immune function. Furthermore, athletes frequently incorporate eccentric exercises into their training regimens or competitive events at these times, yet the inflammatory responses linked to this type of exercise remain unclear. Aim: The aim of this study was to investigate the impact of day time (morning vs. evening) eccentric exercise on inflammatory cytokines, antioxidant enzymes, and hormonal responses in physically active men. Methods: Using a randomized crossover design, twelve active men engaged in a session of plyometric type eccentric exercise (i.e., depth jump, 15 sets of 10 repetitions) in the morning and evening sessions, with blood samples collected pre (T1), immediately post (T2) and 1-h post-exercise (T3), to assess alterations in inflammatory cytokines (interleukin-6 [IL-6], IL-10, IL-1ra, and tumor necrosis factor alpha [TNF-α]), antioxidant enzymes (catalase [CAT], superoxide dismutase [SOD]), and glutathione peroxidase [GPx]), and hormonal changes (testosterone and cortisol). Results: Both the morning and evening eccentric exercise sessions indicated elevations in the cytokines with peak values at T2 (p=0.001), and enhancements of CAT and SOD with peaking values at T3 (p=0.001). While in the GPx, both the groups indicated their peaking elevations at the T2 (p=0.001). Morning group exhibited greater testosterone and cortisol concentrations than the evening group (p < 0.05), but these concentrations remained unchanged after the eccentric exercise session. A significant group × time interaction was observed in IL-6 (p=0.014), IL-10 (p=0.039), IL-1ra (p=0.001), TNF-α (p=0.021), CAT (p=0.046), SOD (p=0.001), GPx (p=0.016), testosterone (p=0.002) and cortisol (p=0.001), revealing greater changes for the evening compared to the morning exercise session. Conclusions: Variations in inflammatory cytokines, antioxidant enzymes, and hormonal responses to eccentric exercise in physically active young male are influenced by the time of day, with more pronounced responses observed in the evening than in the morning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.