ArticleJournal of family medicine and primary care2025
Marchiafava-Bignami disease: A rare entity in chronic alcoholic with a poor prognosis.
Article in Journal of family medicine and primary care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marchiafava-Bignami disease (MBD) is a rare neurological disorder characterized by demyelination and necrosis of the corpus callosum, often seen in people with alcohol use disorder, and chronic malnutrition leads to hypovitaminosis (vitamin B1 deficiency), decreased synthesis of neurotransmitters, failure to synthesize glutamine, and decreased myelin synthesis, leading to decreased self-defense against oxidative stress. This case report describes a 32-year-old man with a complex medical history, including alcohol dependence, who presented with neurological symptoms such as altered sensorium and convulsion. Diagnostic imaging via magnetic resonance imaging (MRI) confirmed MBD. Given the patient's nutritional status, treatment focused on parenteral B vitamin supplementation, particularly thiamine and other B vitamins, which are critical for neurological function. The patient showed no significant improvement in neurological symptoms following vitamin therapy, which highlights a poor prognosis in chronic alcoholism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.