Evidence map›Paper›PMID 41041166›Full record

ArticleImaging neuroscience (Cambridge, Mass.)2025

Characterization of normative fetal rhesus macaque brain development with magnetic resonance imaging.

Joshua A Karpf, Kara E Garcia, Vergina C Cuzon Carlson, Kathleen A Grant, Jamie O Lo, Christopher D Kroenke

Abstract read
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joshua A KarpfDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, United States.
Kara E GarciaDepartment of Radiology & Imaging Sciences, Indiana University School of Medicine, Evansville, IN, United States.
Vergina C Cuzon CarlsonDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, United States.
Kathleen A GrantDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, United States.
Jamie O LoDivision of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, United States.
Christopher D KroenkeDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, United States.

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
BIOLOGICAL BASES OF ALCOHOLISMT32AA007468 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Andrey E Ryabinin · 1987 to 2026
$11.3M
Monkey Alcohol Tissue Research Resource (MATRR)R24AA019431 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Mary Lauren Benton, Verginia Carmella Cuzon Carlson · 2010 to 2026
$10.3M
Early Identification of Neurodevelopmental Disorders with in utero MRIF31MH138114 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI Joshua Karpf · 2025 to 2026
$103k
NIAAA NIH HHS R24 AA019431NIAAA NIH HHS T32 AA007468NIH HHS P51 OD011092NIMH NIH HHS F31 MH138114
6 · The paper itself

Abstract

Advances in motion correction magnetic resonance imaging methods have made it possible to track anatomical changes throughout the highly dynamic phase of fetal neurodevelopment. Characterizing the trajectory of normative brain development provides insight into the underlying biological processes driving growth, as well as a framework for identifying deviations that may be etiological markers of neurodevelopmental disorders. Rhesus macaques, which exhibit similar gestational neurodevelopmental timelines to humans, can be used to address the challenges of obtaining accurate longitudinal fetal imaging measurements and are a key preclinical resource for investigating experimental developmental perturbations. Additionally, the ability to examine biological factors including age and sex can provide important information regarding individual variability in development, but this is often precluded due to limitations in nonhuman primate samples, especially during gestation. To provide updated rhesus macaque magnetic resonance fetal templates allowing for the characterization of normative neurodevelopmental trajectories, we leveraged a unique, large mixed-longitudinal sample of 50 normally developing rhesus macaque fetuses (28 female and 22 male) scanned longitudinally and cross-sectionally

Indexed as

fetalgestationmagnetic resonance imagingneurodevelopmentrhesus macaquesexual dimorphism

Identifiers

PMID41041166
PMCPMC12487360

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.