SynthesisFrontiers in nutrition2025
Dissecting the causal association of diet with thyroid cancer: a systematic review with meta-analysis and mendelian randomization analysis.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Dairy product consumption and thyroid cancer risk: a systematic review and meta-analysis of observational studies.Translational cancer research · 2026Article
- Exploring the link between nitrate exposure and thyroid cancer: A nationwide state-level analysis.Journal of the Endocrine Society · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Diet is a recognized risk factor for cancer. Recently, the role of improving thyroid-related functions through diet has been questioned. This systematic review investigates the relationship between food groups/dietary patterns and thyroid cancer. Methods: We conducted a systematic search of the literature through April 2025 in the PubMed, Scopus, Web of Science, and Embase database following PRISMA guidelines. ORs, HRs or RRs with 95% CIs were extracted as effect sizes and publication bias was assessed using funnel plots. Additionally, we conducted mendelian randomization (MR) analysis by selecting dietary factors (including nutrients) associated with thyroid cancer as exposure data to complement the results of meta-analysis. Results: We collected data from 16 cohort and 21 case-control studies that met the collection criteria. Meta-analysis found that high consumption of fish and alcohol-containing beverages was associated with a reduced risk of thyroid cancer, whereas consumption of high amounts of refined cereal and nitrates increased thyroid cancer risk ( Conclusion: This comprehensive study investigated the relationships between dietary factors and thyroid cancer risk, synthesizing findings from a meta-analysis of observational studies and MR analysis to estimate causal associations. Consistently, both the meta-analysis and MR analysis revealed that consumption of certain types of fish may be linked to a decreased risk of thyroid cancer. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD420251101506.
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