ArticleFrontiers in nutrition2025
Mapping gray matter changes in anorexia nervosa: a functional connectivity network approach.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Identification of critical brain regions for young adults with obesity and their relationships with impulsivity using machine learning based on neuroanatomical features.International journal of obesity (2005) · 2026Article
- Multimodal network localization of brain abnormalities and neuromodulation target identification in obsessive-compulsive disorder.Scientific reports · 2026Article
- Brain network localization of anhedonia.Translational psychiatry · 2026Article
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Authors and funding
8 authors.
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Abstract
Background: Studies using voxel-based morphometry (VBM) have shown considerable variability in gray matter (GM) changes in anorexia nervosa (AN). However, it remains unclear whether these changes converge on common brain networks underlying the disorder. Methods: A systematic review was conducted using the PubMed, Embase, and Web of Science databases to identify studies on whole-brain GM alterations in AN published up to October 10, 2024. The Human Connectome Project (HCP) dataset ( Results: A total of 26 studies involving 667 individuals with AN and 659 healthy controls (HC) were included in this study. Combining the HCP dataset and the FCNM technique, we demonstrated that the disrupted neural networks primarily involved the auditory network, ventral default mode network (DMN), dorsal DMN, and sensorimotor network (SMN). Subgroup analyses further revealed differences in the affected neural networks across specific subgroups, including females-only, adolescents, and adults. Conclusion: The heterogeneous GM alterations in AN can be attributed to common abnormalities within the auditory network, DMN, and SMN. These disruptions are linked to distorted body image, impaired emotional regulation, and disrupted sensory-motor integration in AN. The FCNM technique provides a unified network-level understanding of the neurobiological mechanisms underlying AN, offering insights for targeted therapeutic strategies.
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