ArticleFrontiers in human neuroscience2025
A pilot study on simultaneous stimulation of the primary motor cortex and supplementary motor area using gait-synchronized rhythmic brain stimulation to improve gait variability in post-stroke hemiparetic patients.
Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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16 authors.
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Abstract
Introduction: Gait impairment is a common and disabling consequence of stroke. While walking speed is a key indicator of recovery, gait variability is closely associated with fall risk and long-term functional decline. Previous studies have suggested that functional interaction between the supplementary motor area (SMA) and primary motor cortex (M1) plays a key role in post-stroke gait control. Rather than stimulating these regions independently, simultaneous activation of the SMA-critical for rhythm modulation and motor planning-and gait-synchronized stimulation of the M1-essential for motor execution-may offer enhanced benefits for gait stability. Objective: To assess the feasibility, safety, and preliminary effects of a combined brain stimulation intervention targeting the SMA and M1 on gait variability and balance in individuals with post-stroke hemiparesis. Methods: Sixteen individuals with stroke within 180 days after the onset, aged 40-90 years, who were able to walk on a treadmill were recruited in this study of multi-center, randomized, controlled pilot trial with a parallel-group design. Participants were randomly allocated to either an intervention group ( Results: All 16 participants completed the intervention without adverse events, indicating high feasibility. The intervention group showed significantly reduced stride time variability on the paretic side and improved Mini-BESTest scores compared to the control group. A significant correlation was observed between reductions in gait variability and improvements in balance. Conclusions: This pilot trial supports the feasibility and safety of a combined SMA and M1 stimulation approach. Preliminary findings suggest potential benefits in reducing gait variability and improving balance after stroke, warranting further investigation in a definitive trial.
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