ArticleInternational journal of clinical pediatric dentistry2025
A Prospective, Blinded Randomized, Active-controlled Clinical Trial to Evaluate the Success of Double Antibiotic Paste in Pulpally Infected Primary Molars.
Article in International journal of clinical pediatric dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: An irreversibly infected carious primary tooth is often treated by pulpectomy or lesion sterilization and tissue repair (LSTR), with the latter employing a triple mix of antibiotics (metronidazole, ciprofloxacin, and minocycline). Recently, double antibiotic paste (DAP-metronidazole and ciprofloxacin) has been shown to be safer with good antimicrobial efficacy and better biocompatibility with stem cells at concentrations of 1 mg/mL drug mix. Aim: To assess the clinical and radiographic success of 1 mg/mL DAP and compare it with calcium hydroxide-iodoform pulpectomy in carious infected primary molars. Methods: Thirty-three infected primary teeth in 7-10-year-old children were randomly selected and divided into two groups-DAP and pulpectomy. After treatment, teeth were restored with stainless steel crowns. The clinical and radiographic success were evaluated every 3 and 6 months respectively, till 1 year. Results: The clinical success was 67% (10/15) in the DAP group and 83% (15/18) in the pulpectomy group at 12 months and was statistically nonsignificant ( Conclusion: The study showed a favorable clinical outcome but a low radiographic success of 1 mg/mL DAP in pulpally infected carious primary molars. Clinical significance: In poor prognostic teeth, DAP may be considered a clinically viable option over the conventionally used high-concentration antibiotic pastes for up to 1 year. How to cite this article: Sharma U, Gill NC, Passi S,
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