Evidence map›Paper›PMID 41040985›Full record

ArticleFrontiers in cellular and infection microbiology2025

Nicorandil reduces the antimicrobial effectiveness of polymyxin E against

Rongqing Zhu, Fangxin Luo, Chenxi Yuan, Ziqian Fang, Yaqin Guo, Bao Meng, Dongmei Zhao, Yanyan Liu, Yi Yang, Yasheng Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rongqing Zhu *Department of Infectious Disease & Anhui Center for Surveillance of Bacterial Resistance, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
Fangxin Luo *Department of Infectious Disease & Anhui Center for Surveillance of Bacterial Resistance, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
Chenxi YuanDepartment of Infectious Disease & Anhui Center for Surveillance of Bacterial Resistance, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
Ziqian FangDepartment of Infectious Disease & Anhui Center for Surveillance of Bacterial Resistance, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
Yaqin GuoDepartment of Infectious Disease & Anhui Center for Surveillance of Bacterial Resistance, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
Bao MengDepartment of Infectious Disease & Anhui Center for Surveillance of Bacterial Resistance, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
Dongmei ZhaoDepartment of Infectious Disease & Anhui Center for Surveillance of Bacterial Resistance, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
Yanyan LiuDepartment of Infectious Disease & Anhui Center for Surveillance of Bacterial Resistance, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
Yi YangDepartment of Infectious Disease & Anhui Center for Surveillance of Bacterial Resistance, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
Yasheng LiDepartment of Infectious Disease & Anhui Center for Surveillance of Bacterial Resistance, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
Jiabin LiDepartment of Infectious Disease & Anhui Center for Surveillance of Bacterial Resistance, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
Liang YuDepartment of Infectious Disease & Anhui Center for Surveillance of Bacterial Resistance, The First Affiliated Hospital, Anhui Medical University, Hefei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nitric oxide (NO) plays a crucial role in bacterial physiology and survival, particularly in relation to antibiotic resistance. The protective role of NO against antibiotics is intricate, and the potential antagonistic interactions between NO donors and polymyxin E remain largely unexplored. This study aimed to evaluate the antagonistic effects of nicorandil, a NO donor, on the bactericidal activity of polymyxin E against

methodsThirty clinical strains were identified as multidrug-resistant

resultsNicorandil counteracted the bactericidal effects of polymyxin E in 16 out of 30 clinical isolates of

conclusionsOur study further elucidated that nicorandil treatment mitigates the bactericidal efficacy of polymyxin E against

Indexed as

Anti-Bacterial AgentsColistinKlebsiella pneumoniaeNicorandilReactive Oxygen SpeciesAnimalsDisease Models, AnimalHumansKlebsiella InfectionsLarvaMiceMicrobial Sensitivity TestsNitric OxideOxidative StressSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAnti-Bacterial AgentsColistinNicorandilNitric OxideReactive Oxygen SpeciesKlebsiella pneumoniaenicorandilnitric oxidepolymyxin Ereactive oxygen species

Identifiers

PMID41040985
PMCPMC12484039

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.