Evidence map›Paper›PMID 41040963›Full record

ArticlePatterns (New York, N.Y.)2025

A novel quantum algorithm for efficient attractor search in gene regulatory networks.

Mirko Rossini, Felix M Weidner, Joachim Ankerhold, Hans A Kestler

Abstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mirko RossiniInstitute for Complex Quantum Systems, Ulm University, 89069 Ulm, Germany.
Felix M WeidnerInstitute of Medical Systems Biology, Ulm University, 89069 Ulm, Germany.
Joachim AnkerholdInstitute for Complex Quantum Systems, Ulm University, 89069 Ulm, Germany.
Hans A KestlerLeibniz Institute on Aging, Fritz Lipmann Institute, 07745 Jena, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Describing gene interactions in cells is challenging due to their complexity and the limited microscopic detail available. Boolean networks offer a powerful, coarse-grained approach to modeling these dynamics using binary agents and their interactions. In this context, attractors-stable states of the system-are associated with biological phenotypes, making their identification biologically important. However, traditional computing struggles with the exponential growth of the state space in such models. Here, we present a novel quantum search algorithm for identifying attractors in synchronous Boolean networks, specifically designed for use on quantum computers. The algorithm iteratively suppresses known attractor basins, increasing the probability of detecting new ones. Unlike classical methods, it guarantees the discovery of a new attractor in each run. Early tests demonstrate strong resilience to noise on current NISQ (noisy intermediate-scale quantum) devices, marking a promising advance toward practical quantum-enhanced biological modeling.

Indexed as

attractor searchBoolean networksgene regulatory networksquantum amplitude suppressionquantum computing

Identifiers

PMID41040963
PMCPMC12485557

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.