The vermian-crest angle: a prediction model for foetal cystic posterior fossa anomalies.

Background: Accurate categorisation of the upward rotation of the foetal cerebellar vermis continues to pose diagnostic challenges in prenatal medicine. Recently, a new parameter of the posterior fossa (PF), known as the vermian-crest angle (VCA), has been evaluated using three-dimensional ultrasound (3D-US) and prenatal magnetic resonance imaging (MRI). Objective: This study aimed to evaluate the performance of the VCA in categorizing PF anomalies using 3D-US and to determine its level of agreement with MRI. Study design: We conducted a cohort study involving confirmed cases of PF anomalies. We measured the VCA using 3D-US and compared our data with previously published reference values obtained through both 3D-US and MRI. For statistical analysis, we employed univariate analysis of variance (ANOVA) followed by Tukey's post-hoc test, receiver operating characteristic (ROC) curve analysis, and the intraclass correlation coefficient (ICC). Results: We identified 53 foetuses at a mean gestational age (GA) of 24.5 (SD 5.45) weeks with Blake's pouch cyst (BPC) ( Conclusion: The VCA may be helpful in categorising PF anomalies using 3D-US, particularly BPC and DWM. The good agreement with MRI measurements reinforces the synergy of these tools in the diagnostic work-up.