ArticleOncology letters2025
Role of long non-coding RNA-mRNA interactions in resveratrol-mediated inhibition of ovarian cancer cell proliferation.
Article in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Ovarian cancer (OC) is a prevalent gynecological malignancy requiring advancements in treatment. Resveratrol (RES), a natural polyphenolic compound, has attracted widespread attention due to its potent anticancer properties. Long non-coding (lnc)RNAs serve crucial regulatory roles in OC pathogenesis. However, the mechanism underlying the RES-mediated inhibition of OC cell proliferation through lncRNA regulation is not fully understood. The present study aimed to assess the role of lncRNAs in RES-mediated inhibition of OC cell growth. The A2780 OC cell line was used as the experimental model to establish control and RES-treated groups. The effect of RES on OC cell migration was also evaluated. Differentially expressed lncRNAs (DELs) were identified after RES treatment. lncRNA-mRNA regulatory networks of tumor-related pathways were constructed and functionally assessed using reverse transcription-quantitative PCR, proliferation assays, and knockdown and overexpression of hub lncRNAs. The results demonstrated that RES significantly inhibited OC cell migration. Moreover, 721 DELs were identified after RES treatment and were predominantly enriched in the p53 signaling pathway and cell cycle regulation associated with tumorigenesis. Key lncRNAs, including
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