ArticleClinical case reports2025
Topical Estradiol Gel Leading to Laboratory Error in Serum Estradiol Measurement: A Diagnostic Pitfall.
Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Topical Estradiol Gel Leading to Laboratory Error in Serum Estradiol Measurement: A Diagnostic Pitfall.Clinical case reports · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Estradiol gel is commonly used as an estrogen replacement therapy for patients with menopausal symptoms. Herein, we present a case of a patient with iatrogenic primary ovarian insufficiency who exhibited an abnormally elevated serum estradiol concentration (5634.0 pg/mL) during routine estradiol monitoring. A detailed interview revealed that the cause of these elevated levels was contamination of the needle used to draw her blood with gel from her skin. To the best of our knowledge, this is the first report of estradiol concentrations exceeding 2000 pg/mL due to such contamination. This phenomenon is not well known and is not described in package inserts or guidelines. There is a risk that misleadingly high serum estradiol concentrations may lead to inappropriate dose adjustments, potentially negatively affecting the health of the patients. Thus, clinicians must provide precise instructions to patients to avoid applying the gel around the area where venipuncture is to be performed.
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