Evidence map›Paper›PMID 41040804›Full record

ArticleArXiv2025

GPU-accelerated FREDopt package for simultaneous dose and LET

Damian Borys, Jan Gajewski, Tobias Becher, Yair Censor, Renata Kopeć, Marzena Rydygier, Angelo Schiavi, Tomasz Skóra, Anna Spaleniak, Niklas Wahl and 2 more

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In one paragraph

Article in ArXiv, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Damian BorysSilesian University of Technology, Department of Systems Biology and Engineering, Gliwice, Poland.
Jan GajewskiInstitute of Nuclear Physics PAN, Krakow, Poland.
Tobias BecherDepartment of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Yair CensorDepartment of Mathematics, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.
Renata KopećInstitute of Nuclear Physics PAN, Krakow, Poland.
Marzena RydygierInstitute of Nuclear Physics PAN, Krakow, Poland.
Angelo SchiaviDipartimento di Scienze di Base e Applicate per l'Ingegneria, La Sapienza Università di Roma, Rome, Italy.
Tomasz SkóraNational Oncology Institute, National Research Institute, Krakow Branch, Krakow, Poland.
Anna SpaleniakInstitute of Nuclear Physics PAN, Krakow, Poland.
Niklas WahlDepartment of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Agnieszka WochnikInstitute of Nuclear Physics PAN, Krakow, Poland.
Antoni RucińskiInstitute of Nuclear Physics PAN, Krakow, Poland.

Funding

Ionization Detail - Biologically based treatment planning for particle therapy beyond LET-RBER01CA266467 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRUCE FADDEGON, Jian-Hua Mao · 2022 to 2026
$3.0M
NCI NIH HHS R01 CA266467
6 · The paper itself

Abstract

This study presents FREDopt, a newly developed GPU-accelerated open-source optimization software for simultaneous proton dose and dose-averaged LET (LET

Indexed as

feasibility seekinglinear energy transfer (LET)proton therapyradiation therapysuperiorizationtreatment plan optimization

Identifiers

PMID41040804
PMCPMC12486063

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.