ReviewCureus2025
Early Exercise Rehabilitation Enhances Gait Following Endoprosthetic Knee Reconstruction for Bone Tumors: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endoprosthetic knee replacement after bone tumor resection is a critical limb-salvage procedure, yet patients often experience persistent gait abnormalities that hinder recovery and quality of life. Few studies have focused on the effects of exercise training on gait and functional ambulation, and potential time-response relationships between exercise training and outcomes remain unclear. We aimed to conduct a systematic review and meta-analysis to evaluate the effect of exercise training on gait. We also aimed to propose a rehabilitation protocol based on state-of-the-art evidence. A systematic search was conducted on databases including MEDLINE, Web of Science, Google Scholar, Cochrane, and Embase following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Studies assessing gait following exercise training in patients after endoprosthetic knee reconstruction were included. Three controlled clinical studies with 576 patients met the inclusion criteria. The pooled effect size was moderate, with Hedges' g for TUG (Timed Up and Go) being -0.569 (95% CI: -0.597 to -0.540). More complex gait parameters showed modest, nonsignificant improvements, particularly when rehabilitation was initiated later. Early structured rehabilitation meaningfully enhances gait symmetry, walking speed, and balance control in patients undergoing knee endoprosthetic replacement after tumor resection. The integration of timely, individualized exercise programs into standard postoperative care may maximize functional recovery and improve mobility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.