Evidence map›Paper›PMID 41040734›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Genome-wide association study of adolescent-onset depression.

Poppy Z Grimes, Brittany L Mitchell, Katherine N Thompson, Qingkun Deng, Xueyi Shen, Jareth C Wolfe, Jodi T Thomas, Robyn E Wootton, Daniel E Adkins, Saranya Arirangan and 63 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

73 authors.

Poppy Z GrimesDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-9913-2382
Brittany L MitchellBrain and Mental Health Program, QIMR Berghofer, Brisbane, Queensland, Australia.
Katherine N ThompsonDepartment of Sociology, Purdue University, West Lafayette, USA.
Qingkun DengDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Xueyi ShenDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Jareth C WolfeDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Jodi T ThomasBrain and Mental Health Program, QIMR Berghofer, Brisbane, Queensland, Australia.
Robyn E WoottonSchool of Psychological Science, University of Bristol, Bristol, UK.
Daniel E AdkinsSociology and Criminology, University of Utah, Salt Lake City, USA.
Saranya AriranganDepartment of Sociology, Purdue University, West Lafayette, USA.
Elham AssarySocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Chris ChatzinakosDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA.
Charlotte A DennisonWolfson Centre for Young People's Mental Health, Cardiff University, Cardiff, UK.
Swathi Hassan GangarajuChild Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
Andreas JangmoDepartment of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway.
Yeongmi JeongDepartment of Sociology, Purdue University, West Lafayette, USA.
Siim KurvitsEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Qingqin S LiNeuroscience, Neuroscience Data Science, Janssen Research & Development, LLC, Titusville, USA.
Ehsan MotazediDepartment of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Joonas NaamankaHector Institute for Artificial Intelligence in Psychiatry, Central Institution of Mental Health, Mannheim, Germany.
Thuy-Dung NguyenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Vanessa K OtaGenetics Division, Department of Morphology and Genetics, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Joëlle A PasmanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Mina ShahisavandiChild and Adolescent Psychiatry, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Amy ShakeshaftWolfson Centre for Young People's Mental Health, Cardiff University, Cardiff, UK.
John R ShorterDepartment of Science and the Environment, Roskilde University, Roskilde, Denmark.
Chloe SlaneyMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Martin TesliAdult Psychiatry Unit, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Carol A WangSchool of Medicine and Public Health, University of Newcastle, Newcastle, Australia.
Uxue Zubizarreta-ArrutiPsychiatric Genetics Unit, Group of Psychiatry Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
PGC MDD Working Group
GLAD+
NIHR BioResource
Silvia AlemanyPsychiatric Genetics Unit, Group of Psychiatry Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Ole A AndreassenCentre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo, Oslo, Norway.
Helga AskPsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.
Sintia I BelangeroGenetics Division, Department of Morphology and Genetics, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Rosa BoschBiomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
Gerome BreenSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Rodrigo A BressanLaboratory of Integrative Neuroscience, Psychiatry, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Alfonso BuilInstitut of Biological Psychiatry, Sank Hans Hospital, Mental Health Services Capital Region Denmark, Roskilde, Denmark.
Enda M ByrneChild Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
Miquel CasasSJD MIND Escoles, Institut de Recerca Sant Joan de Deu, Hospital Sant Joan de Deu, Esplugues de Llobregat, Spain.
William E CopelandPsychiatry, University of Vermont, Burlington, USA.
Thalia C EleySocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Laurie J HanniganResearch Department, Lovisenberg Diaconal Hospital, Oslo, Norway.
Catharina A HartmanInterdisciplinary Center Psychopathology and Emotion regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Alexandra HavdahlPsychGen Centre for Genetic Epidemiology and Mental Health, Division of Public Health and Prevention, Norwegian Institute of Public Health, Oslo, Norway.
Ian B HickieBrain and Mind Centre, University of Sydney, Sydney, Australia.
Golam M KhandakerMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Kelli LehtoEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Hermine MaesVirginia Institute of Psychiatric and Behavioral Genetics, Cellular, Molecular and Genetic Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Nicholas G MartinBrain and Mental Health Program, QIMR Berghofer, Brisbane, Queensland, Australia.
Alexander NeumannChild and Adolescent Psychiatry, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Albertine J OldehinkelInterdisciplinary Center Psychopathology and Emotion regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Pedro M PanLaboratory of Integrative Neuroscience, Psychiatry, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Hong PanInstitute for Human Development and Potential, Agency for Science, Technology and Research (A*STAR), Singapore.
Craig E PennellSchool of Medicine and Public Health, University of Newcastle, Newcastle, Australia.
Roseann E PetersonInstitute for Genomics in Health, Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA.
Alina RodriguezInstitute for Human Development and Potential, Agency for Science, Technology and Research (A*STAR), Singapore.
Giovanni A SalumPsychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Tanja Gm VrijkotteDepartment of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Robbee WedowDepartment of Sociology, Purdue University, West Lafayette, USA.
Andrew Jo WhitehouseThe Kids Research Institute Australia, The University of Western Australia, Perth, Australia.
Anita ThaparWolfson Centre for Young People's Mental Health, Cardiff University, Cardiff, UK.
Henrik LarssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Christel M MiddeldorpChild Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
Andrew McIntoshDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Mark J AdamsDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Yi LuDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Heather C WhalleyDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Alex Sf KwongDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

Funding

A Trans-Nordic Study of Extreme Major DepressionR01MH123724 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PATRICK F SULLIVAN, Lu Yi · 2020 to 2026
$4.7M
NIMH NIH HHS R01 MH123724Wellcome Trust
6 · The paper itself

Abstract

Adolescent depression is a heritable psychiatric condition with rising global prevalence and severe long-term outcomes, yet its biological underpinnings remain poorly understood. We conducted the first genome-wide association study of adolescent-onset depression, comprising 102,428 cases (diagnosis or clinical symptom thresholds) and 286,911 controls, including diverse ancestries. Cross-ancestry meta-analysis identified 52 independent variants across 17 loci; European-only analysis found 61 variants at 29 loci, with a SNP-based heritability of 9.8%. Comparative analyses revealed two genes unique to adolescent-onset versus lifetime depression, enriched in neuronal subtypes, and two genes as potential drug repurposing targets. Polygenic scores were associated with adolescent-onset depression across ancestries, persistent depression trajectories, more severe outcomes, as well as reduced cortical volume, surface area and white matter integrity. Genetic correlation and Mendelian randomisation analyses support shared genetic liability and causal links with early puberty and modifiable health and behavioural risk factors. These findings uncover novel genetic loci and refine biological pathways underlying adolescent-onset depression, revealing age-specific mechanisms and early intervention opportunities.

Identifiers

PMID41040734
PMCPMC12485989

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.