Evidence map›Paper›PMID 41040705›Full record

ArticlemedRxiv : the preprint server for health sciences2025

CSF proteogenomics implicates novel proteins and humoral immunity in Alzheimer's disease risk.

Aliza P Wingo, Yue Liu, Zhen Mei, Michael Wang, Selina M Vattathil, Ekaterina S Gerasimov, Anantharaman Shantaraman, Fang Wu, Duc M Duong, Edward J Fox and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Aliza P WingoVA Northern California Healthcare System, Sacramento, CA, USA.ORCID 0000-0002-6360-6726
Yue LiuDepartment of Neurology, University of California, Davis, Sacramento, CA, USA.
Zhen MeiDepartment of Neurology, University of California, Davis, Sacramento, CA, USA.
Michael WangDepartment of Psychiatry, University of California, Davis, Sacramento, CA, USA.
Selina M VattathilDepartment of Neurology, University of California, Davis, Sacramento, CA, USA.ORCID 0000-0001-5616-4184
Ekaterina S GerasimovDepartment of Psychiatry, University of California, Davis, Sacramento, CA, USA.
Anantharaman ShantaramanDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Fang WuDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Duc M DuongDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Edward J FoxDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Alzheimer’s Disease Neuroimaging Initiative
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Allan I LeveyCenter for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA.
Nicholas T SeyfriedDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-4507-624X
Thomas S WingoDepartment of Neurology, University of California, Davis, Sacramento, CA, USA.ORCID 0000-0002-7679-6282

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
The Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI ALLAN I LEVEY · 2020 to 2026
$29.0M
Multi-omic network-directed proteoform discovery, dissection and functional validation to prioritize novel AD therapeutic targetsU01AG061356 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2018 to 2022
$13.7M
Supplement to AMP-AD Brain Proteomic Network Enhancement, Validation and Translation into CSF BiomarkersU01AG061357 · NIA · EMORY UNIVERSITY · PI LEVEY, ALLAN I, SEYFRIED, NICHOLAS THOMAS · 2018 to 2022
$9.1M
Discovery of Novel Proteomic Targets in Alzheimer's DiseaseU01AG046161 · NIA · EMORY UNIVERSITY · PI BENNETT, DAVID ALAN, GESCHWIND, DANIEL H · 2014 to 2018
$8.4M
Novel Protein Biomarkers of Corticolimbic Pathophysiology in Lewy body DementiaU01NS128433 · NINDS · EMORY UNIVERSITY · PI ALLAN I LEVEY, Nicholas Thomas Seyfried · 2022 to 2026
$6.7M
The brain multi-omic approach to identify key molecular drivers of neuropsychiatric symptoms in Alzheimer's dementiaR01AG072120 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Aliza Pham Wingo, Thomas Spurgeon Wingo · 2022 to 2026
$4.3M
Glycoproteomics and the Glycosylation Code of the Brain in Asymptomatic and Symptomatic Alzheimer’s DiseaseRF1AG062181 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CUMMINGS, RICHARD D, SEYFRIED, NICHOLAS THOMAS · 2018 to 2018
$4.1M
Integrative genomic, transcriptomic, and proteomic analyses to investigate sex-specific differences in Alzheimer's DiseaseR01AG075827 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Aliza Pham Wingo, Thomas Spurgeon Wingo · 2022 to 2026
$3.7M
Air pollution and early signs of dementiaR01AG079170 · NIA · EMORY UNIVERSITY · PI Anke Huels, Thomas Spurgeon Wingo · 2022 to 2026
$3.6M
BLRD VA I01 BX005686BLRD VA IK4 BX005219NIA NIH HHS P30 AG066511NIA NIH HHS R01 AG072120NIA NIH HHS R01 AG075827NIA NIH HHS R01 AG079170NIA NIH HHS RF1 AG062181NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG046161NIA NIH HHS U01 AG061356NIA NIH HHS U01 AG061357NINDS NIH HHS U01 NS128433
6 · The paper itself

Abstract

We profiled 2,961 cerebrospinal fluid (CSF) proteins in 1,005 participants of the Alzheimer's Disease Neuroimaging Initiative (ADNI), including 1,066 proteins not measured in prior studies, using mass spectrometry (MS). We mapped protein quantitative trait loci (pQTLs) in CSF, compared them with brain and plasma pQTLs, and integrated them with Alzheimer's disease (AD) genome-wide association study (GWAS) data. We identified 1,417 index

Identifiers

PMID41040705
PMCPMC12485993

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.