SynthesisFrontiers in pediatrics2025
The effect of intrapartum maternal fever on neonatal outcomes: a systematic review and meta-analysis.
Synthesis in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Impact of First-Trimester Vaginal Microecology on Spontaneous Abortion: A Retrospective Cohort Study.Pathogens (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To systematically review the link between intrapartum maternal fever and adverse neonatal outcomes in term singleton pregnancies not complicated by chorioamnionitis. Methods: The PubMed, Web of Science, Scopus, and Embase databases were searched for studies published up to June 30, 2024, that reported data on women with term singleton pregnancies and intrapartum fever. Studies describing cases of chorioamnionitis (CAM) were excluded. The included studies had to have defined exclusion criteria to ensure that women with a high likelihood of CAM were excluded. Neonatal outcomes of interest were infection/sepsis, fetal distress, assisted ventilation, low APGAR scores, neonatal intensive care unit (NICU) admission, seizures, and hypotonia. Study quality was assessed by the Newcastle-Ottawa Scale (NOS). A random-effects model was used to pool effect sizes, which were reported as odds ratios (OR) and weighted mean differences (WMD). Funnel plots and Egger's test were used to assess publication bias. Results: A total of 11 studies ( Conclusion: Intrapartum maternal fever appears to be associated with increased risks of adverse neonatal outcomes. However, the challenge of entirely excluding CAM-related fever and variability in study methodologies limits the robustness of the findings. Nonetheless, proactive management of maternal fever during labor could be critical. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024565830, PROSPERO CRD42024565830.
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Registered trials
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