ArticleJournal of dental sciences2025
Effects of sodium hypochlorite on the viability and osteogenic differentiation of dental pulp stem cells in regenerative pulp therapy.
Article in Journal of dental sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Pioneering next-generation bioactive materials for endodontics: Insights of mitochondrial biology.Bioactive materials · 2026Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/purpose: Regenerative pulp therapy's efficacy is constrained by root canal disinfectants' effects on residual dental pulp stem cells. This study investigates sodium hypochlorite's influence on dental pulp stem cells (DPSCs) viability, mitochondrial function, and osteogenic differentiation, providing cellular and molecular foundations for optimizing clinical protocols. Materials and methods: Human deciduous teeth-derived DPSCs were treated with sodium hypochlorite (0.5%-5%) for 1 min. Cell viability, cytoskeletal integrity, and mitochondrial morphology were assessed Results: Sodium hypochlorite exhibited concentration-dependent effects. At ≤1%, DPSCs maintained >80% viability with intact cytoskeleton, while ≥3% significantly inhibited proliferation and induced mitochondrial autophagy. Low concentration (0.5%) minimally affected osteogenic differentiation markers, while higher concentrations progressively suppressed osteogenic potential. Conclusion: Low-concentration sodium hypochlorite (≤0.5 %) preserves DPSC viability, mitochondrial function, and differentiation capacity, whereas higher concentrations impair cellular functions through autophagy induction. These findings support using lower concentrations in regenerative endodontics to maintain stem cell potential while ensuring adequate disinfection.
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