ArticleJournal of dental sciences2025
Recombinant human fibroblast growth factor-2 promotes surgical-wound healing in the rat gingiva.
Article in Journal of dental sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Fibroblast Growth Factor-2 and Enamel Matrix Derivative Enhance Proliferation, Migration, and Wound Healing in Gingival Epithelial and Fibroblast Cells.Medicina (Kaunas, Lithuania) · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/purpose: Fibroblast growth factor-2 (FGF-2) has been shown to promote periodontal tissue regeneration in clinical settings. However, reports on the effects of FGF-2 on soft-tissue wound healing after periodontal surgery are scarce. This study aimed to investigate the effects of FGF-2 on gingival wound healing. Materials and methods: Seven-week-old male Sprague-Dawley rats were divided into three groups. Each group included 15 rats, with five animals in each experimental period. Five untreated rats were used as the no-treated group. Incisions were made bilaterally in the palatal mucosa from the mesial corner of the maxillary first molar up to the incisor, full-thickness flaps were raised, and sutures were placed. In the control group, no additional treatment was performed, whereas in the FGF-2 and enamel matrix derivative (EMD) groups, FGF-2 and EMD were applied before suturing, respectively. Animals in all groups were euthanized 1, 3, and 7 days, and the maxilla was resected. The re-epithelialization, gingival thickness, inflammation, and angiogenesis were evaluated histopathologically. Results: The FGF-2 group showed significantly greater re-epithelialization than the control group on day 1. The FGF-2 group showed significantly greater gingival thickness than the other two groups at all time points. The FGF-2 group showed significantly lesser inflammation than the control group on day 1. The FGF-2 group showed significantly higher angiogenesis than the control group on days 1 and 3. Conclusion: FGF-2 promotes re-epithelialization, and increases angiogenesis and gingival thickness. Additionally, FGF-2 reduces the inflammatory response during wound healing.
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