Association between dental scaling and the lower risk of oral cancer: A population-based nested case-control study.

Background/purpose: Oral cancer is a common malignancy that associates with oral inflammatory reactions. Dental scaling can effectively reduce periodontal inflammation to facilitate oral health. This may contribute to a less conducive environment for oral cancer initiation and progression. The aim of this study was to investigate the association between dental scaling and oral cancer. Materials and methods: A retrospective nested case-control study was conducted by using Taiwanese Longitudinal Health Insurance Database. This study captured patients with oral cancer identified from the cancer registry. Each oral cancer patient was matched with eight non-oral cancer controls based on age and sex. Conditional logistic regression was use to assess the association between the last dental scaling prior to the index date and oral cancer occurrence. Results: Dental scaling significantly lowered the risk of oral cancer occurrence (aOR: 0.75, 95 % CI: 0.67-0.85). Individuals with different intervals of dental scaling prior to the index date showed a lower rate of oral cancer than those who did not received dental scaling ( Conclusion: Taken together, this nationwide population-based study indicated that dental scaling exhibited a significantly lower risk of oral cancer in Taiwanese population.