ArticleJournal of dental sciences2025
In vitro evaluation of novel composite bioceramic filaments for alveolar bone regeneration.
Article in Journal of dental sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Comparative in vivo study of 3D-printed composite bioceramic scaffolds fabricated by distinct pre-processing methods.Journal of dental sciences · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/purpose: Alveolar bone defect repair remains a major clinical challenge in oral and maxillofacial reconstruction. This study developed 3D-printable composite filaments combining polylactic acid (PLA) with bioceramic powders and evaluated their physicochemical properties and in vitro osteogenic potential for alveolar bone graft applications. Materials and methods: Filaments were fabricated via hot processing and tetrahydrofuran (THF) solvent casting, blending PLA with hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) at a 7:3 ratio. Four groups, H-PLA (heated PLA), H-MIX (heated PLA with HA/β-TCP), T-PLA (THF-processed PLA), and T-MIX (THF-processed PLA with HA/β-TCP) groups, underwent material characterization such as Fourier transform infrared spectroscopy (FTIR), X-ray diffractometer (XRD), scanning electron microscopy (SEM), and compressive strength testing, and MC3T3 cell-based assays for biocompatibility assessment. Results: H-MIX and T-MIX significantly enhanced compressive strength and osteogenic mineralization compared to PLA-only groups. HA/β-TCP was uniformly dispersed within the PLA matrix. Cell proliferation peaked on day 3, with both composite groups showing higher viability than controls ( Conclusion: Composite scaffolds made by thermal and solvent casting showed enhanced mechanical strength and osteogenic activity in vitro. T-MIX outperformed other groups in compressive strength, ALP activity, and calcium deposition. These results indicate that HA/β-TCP-reinforced PLA filaments, especially T-MIX, are promising for alveolar bone repair.
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Registered trials
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