Evidence map›Paper›PMID 41040581›Full record

ArticleJournal of dental sciences2025

Brain activation generated by periodontal initial treatment.

Kosuke Muraoka, Masafumi Oda, Kenichi Yoshino, Tatsurou Tanaka, Masaki Morishita, Taiji Nakamura, Shino Yamaguchi, Kazuo Sonoki, Yasuhiro Morimoto, Keisuke Nakashima and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kosuke MuraokaDivision of Clinical Education Development and Research, Faculty of Dentistry, Kyushu Dental University, Kitakyushu, Japan.
Masafumi OdaDivision of Oral and Maxillofacial Radiology, Kyushu Dental University, Kitakyushu, Japan.
Kenichi YoshinoSection of Primary Dental Education, Kyushu Dental University, Kitakyushu, Japan.
Tatsurou TanakaGraduate School of Medical and Dental Sciences, Department of Maxillofacial Radiology, Kagoshima University, Kagoshima, Japan.
Masaki MorishitaDivision of Clinical Education Development and Research, Faculty of Dentistry, Kyushu Dental University, Kitakyushu, Japan.
Taiji NakamuraDivision of Periodontology, Kyushu Dental University, Kitakyushu, Japan.
Shino YamaguchiSchool of Oral Health, Kyushu Dental University, Kitakyushu, Japan.
Kazuo SonokiSonoki Internal Medicine Clinic, Fukuoka, Japan.
Yasuhiro MorimotoDivision of Oral and Maxillofacial Radiology, Kyushu Dental University, Kitakyushu, Japan.
Keisuke NakashimaDivision of Periodontology, Kyushu Dental University, Kitakyushu, Japan.
Shuji AwanoDivision of Clinical Education Development and Research, Faculty of Dentistry, Kyushu Dental University, Kitakyushu, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/purpose: There is a close relationship between the dental field and the cognitive function of the brain. The aim of this research was to examine the effect of periodontal initial treatment on brain functional activity. Materials and methods: The subjects were 16 patients with periodontitis. After informed consent was obtained, periodontal initial treatment included brushing instruction, scaling and root planing. No occlusal adjustments were conducted. Periodontal examination and functional magnetic resonance imaging (fMRI) were performed at the initial visits and subsequent reassessments. Results: Periodontal tissue improved significantly after periodontal initial treatment. From fMRI testing, during both the language and calculation task, brain activity in the dorsolateral prefrontal cortex and Wernicke's area were observed to have increased compared to the initial visit. Conclusion: Periodontal disease causes functional impairment of working memory and selective attention. These findings suggested that the periodontal initial treatment aid in restoring brain function.

Indexed as

Brain activationCalculation taskfMRILanguage taskPeriodontal initial treatment

Identifiers

PMID41040581
PMCPMC12485417

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.