Evidence map›Paper›PMID 41040564›Full record

ArticleJournal of dental sciences2025

Human umbilical cord mesenchymal stem cells secretome and nanoemulsion propolis combination ameliorate osteoclastogenesis in lipopolysaccharide-induced osteolysis in hyperglycemia rats.

Alexander Patera Nugraha, Kunhua Yang, Adya Pramusita, Nurul Aisyah Rizky Putranti, Muhammad Luthfi, Nastiti Faradilla Ramadhani, Ratri Maya Sitalaksmi, Putri Cahaya Situmorang, Muh Ade Artasasta, Ananto Ali Alhasyimi and 5 more

Erratum issuedAbstract read
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In one paragraph

Article in Journal of dental sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Alexander Patera NugrahaDental Regenerative Research Group, Department of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Kunhua YangDivision for Globalization Initiative, Liaison Center for Innovative Dentistry, Graduate School of Dentistry, Tohoku University, Sendai, Japan.
Adya PramusitaDental Regenerative Research Group, Department of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Nurul Aisyah Rizky PutrantiDental Regenerative Research Group, Department of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Muhammad LuthfiDepartment of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Nastiti Faradilla RamadhaniDepartment of Dentomaxillofacial Radiology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Ratri Maya SitalaksmiDepartment of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Putri Cahaya SitumorangBiology Study Program, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia.
Muh Ade ArtasastaBiotechnology Program, Departement of Applied Science, Faculty of Mathematics and Natural Science, Universitas Negeri Malang, Malang, Indonesia.
Ananto Ali AlhasyimiDepartment of Orthodontics, Faculty of Dentistry, Universitas Gadjah Mada, Special Region of Yogyakarta, Indonesia.
Wibi RiawanDepartment of Biomolecular Biochemistry, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Albertus Putera NugrahaFaculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Khairul Anuar ShariffSchool of Materials and Mineral Resources Engineering, Engineering Campus, Universiti Sains Malaysia, Penang, Malaysia.
Kotaro TanimotoDepartment of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate Schoolof Biomedical and Health Sciences, Hiroshima, Japan.
Guang HongDivision for Globalization Initiative, Liaison Center for Innovative Dentistry, Graduate School of Dentistry, Tohoku University, Sendai, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/purpose: Human umbilical cord mesenchymal stem cell secretome (HUCMSCS) and nanoemulsion propolis (NEP) from Tetragonula biroi may be beneficial regenerative medicine to reduce LPS-induced osteolysis with hyperglycemia. This study aimed to investigate the HUCMSCS and NEP effect on nuclear factor associated T-cell-1 (NFATc1), sclerostin, receptor activator kappa beta (RANK), its ligand (RANKL), the osteoprotegerin (OPG) expression, tartrate-resistant acid phosphatase (TRAPase), and cathepsin K (Ctsk) serum level in LPS-induced osteolysis in hyperglycemic Wistar rats ( Materials and methods: Twenty-eight healthy male Wistar rats, 1-2 months old and 250-300 g body weight, were divided into seven groups, namely K1: control group; K2: 100 μl LPS; K3: hyperglycemia (≥230 mg/dL); K4: 100 μl LPS with hyperglycemia; K5: LPS, hyperglycemia, and 100 μl NEP; K6: LPS, hyperglycemia, and 100 μl HUCMSCS; and K7: LPS, hyperglycemia, and 100 μl HUCMSCS and NEP. Results: Conclusion: HUCMSCS and NEP post-administration reduced osteoclastogenesis in LPS-induced osteolysis calvaria with hyperglycemic

Indexed as

Diabetes mellitusInflammationLipopolysaccharideMedicineOsteoclastogenesisStem cells

Identifiers

PMID41040564
PMCPMC12485425

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.