ArticleJournal of dental sciences2025
Serotonin promotes lip sensory recovery after inferior alveolar nerve transection via histone serotonylation.
Article in Journal of dental sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Development of Acellular Matrix-Based Bioprinted Scaffold for Inferior Alveolar Nerve Regeneration.ACS omega · 2026Article
- Beyond neurotransmission: the roles of serotonylation in physiological and pathological processes.Cellular & molecular biology letters · 2026Review
- Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/purpose: Sensory impairment due to Inferior alveolar nerve injury in mandibular tumor ablation severely impairs the survivors' quality of life. This study explored the role of serotonin in lip sensory recovery after inferior alveolar nerve transection. Materials and methods: We established an Results: Lip sensory functions could recover without additional interventions within 4 weeks. Serotonin production, histone serotonylation, and transglutaminase 2 were upregulated in the ipsilateral trigeminal ganglia. Exogenous serotonin could improve axon growth with histone serotonylation. Additional serotonin could slightly compress the lip sensory recovery time, and an increase in histone serotonylation and axon growth-related molecules were observed in the ipsilateral trigeminal ganglia. Oppositely, GK921 significantly reduced the axon length and delayed the lip sensory recovery after inferior alveolar nerve transection. Conclusion: Serotonin could accelerate the lip sensory recovery after inferior alveolar nerve transection via increasing histone serotonylation. These results may offer a potential therapeutic approach for peripheral nerve injury and studies may be needed to validate the efficacy in other peripheral nerve injury models.
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