SynthesisFrontiers in oncology2025
Perioperative immune checkpoint inhibitors in elderly patients with resectable NSCLC: a systematic review and meta-analysis.
Synthesis in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Perioperative immunotherapy has shown promising results in patients with resectable stage II-III non-small cell lung cancer (NSCLC). However, its benefits for the specific subgroup of elderly patients remain unclear. This study aims to evaluate the efficacy of perioperative immunotherapy in elderly NSCLC patients aged 65 and above, focusing on key metrics such as pathological complete response (pCR), event-free survival (EFS), and overall survival (OS). Methods: We conducted a comprehensive meta-analysis of randomized clinical trials that reported subgroup data on elderly patients regarding pCR rates and hazard ratios (HRs) for EFS and OS. Data were retrieved from PubMed, EMBASE, and proceedings of oncology conferences from January 2020 to June 2025.A fixed effects model was used for the meta-analysis. Aggregated pooled HRs for time-to-event outcomes (EFS and OS), odds ratios (OR) and risk ratios (RRs) for dichotomous outcomes (pCR) were calculated specifically for patients aged ≥65 years who received perioperative immunotherapy or placebo. Results: A total of 8 randomized controlled trials involving 1561 patients aged ≥65 years with resectable NSCLC were included. A significant benefit was observed in terms of pCR (risk ratio, 5.26; 95% CI, 3.54 - 7.82; I² = 0%) and EFS (HR, 0.64; 95% CI, 0.55 - 0.74; I² = 7%) for patients aged ≥65 years who received perioperative immunotherapy compared with placebo. Conclusion: Our systematic review and meta-analysis demonstrated that perioperative immunotherapy was superior to placebo in terms of pathological and event-free survival for patients aged ≥65 years. These findings provide age-specific evidence to inform precision decision-making for treating the elderly patients. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD420250654072.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.