Case report: Histiocytic sarcoma as transdifferentiation of a marginal zone lymphoma-a case presentation based on

Background: Histiocytic sarcoma (HS) is a rare and aggressive hematopoietic malignancy characterized by the proliferation of cells resembling mature histiocytes. It typically presents in extranodal sites such as the skin, the gastrointestinal tract, and soft tissues and is often accompanied by systemic symptoms including fever and weight loss. HS occurs Case presentation: We describe a 66-year-old female patient who presented primarily with abdominal pain and constitutional symptoms. The clinical evaluation showed significant hepatosplenomegaly and lymphadenopathy. A liver biopsy demonstrated a sinus-associated spread of HS. The patient died of suspected hemorrhagic shock before the diagnostic results were finalized and before rescue treatment could be initiated. The autopsy findings confirmed a widespread metastatic HS and concurrent MZL. The molecular analysis showed that both neoplasmas were clonally related, supporting the hypothesis of transformation/transdifferentiation of MZL into HS. Conclusion: We have reported the fifth unusual transformation of a MZL into a HS. Transformed/transdifferentiated HS is a rare and aggressive neoplasm. Evidence from the published case reports suggests that its clinical course may be more severe than