Evidence map›Paper›PMID 41040510›Full record

ReviewFrontiers in oncology2025

Influence factor and mechanism of FLASH effect.

Tingyu Feng, Tianyang He, Wentao Ye, Lisha Xiang

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Tingyu FengDivision of Thoracic Tumor Multimodality Treatment and Department of Medical Oncology, Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Tianyang HeWest China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.
Wentao YeWest China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.
Lisha XiangDivision of Thoracic Tumor Multimodality Treatment and Department of Medical Oncology, Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

FLASH radiotherapy (FLASH-RT) represents an innovative treatment modality utilizing ultra-high dose-rate irradiation (>40 Gy/s). The FLASH effect, induced by FLASH-RT, is characterized by the selective radioprotective effect of normal tissue while preserving tumor control efficacy. Currently, FLASH effect has been confirmed in many preclinical studies and clinical studies. However, the mechanism and the influencing factors of FLASH effect remain ambiguous. This review systematically summarizes current understanding of the mechanism and influencing factors of FLASH effect, providing theoretical basis for the future study and application of FLASH-RT.

Indexed as

FLASH effectFLASH radiotherapyinfluencing factormechanismultra-high dose-rate

Identifiers

PMID41040510
PMCPMC12483931

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.