Evidence map›Paper›PMID 41040429›Full record

ArticleFrontiers in clinical diabetes and healthcare2025

DNA damage and repair in patients with early chronic kidney disease with or without type 2 diabetes.

Jorge Andrade-Sierra, Leonardo Pazarín-Villaseñor, Andrés García-Sánchez, Ernesto Germán Cardona-Muñoz, Wendy Campos-Pérez, Erika Martínez-López, Tannia Isabel Campos-Bayardo, Daniel Román-Rojas, Luis Francisco Gómez-Hermosillo, Jorge Casillas-Moreno and 4 more

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Article in Frontiers in clinical diabetes and healthcare, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Jorge Andrade-SierraNephrology Service, Civil Hospital of Guadalajara "Dr. Juan I Menchaca", Guadalajara, Jalisco, Mexico.
Leonardo Pazarín-VillaseñorNephrology Service, Civil Hospital of Guadalajara "Dr. Juan I Menchaca", Guadalajara, Jalisco, Mexico.
Andrés García-SánchezDepartment of Physiology, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco, Mexico.
Ernesto Germán Cardona-MuñozDepartment of Physiology, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco, Mexico.
Wendy Campos-PérezDepartment of Molecular Biology and Genomics, Institute of Nutrigenetics and Translational Nutrigenomics, University of Guadalajara, Guadalajara, Jalisco, Mexico.
Erika Martínez-LópezDepartment of Molecular Biology and Genomics, Institute of Nutrigenetics and Translational Nutrigenomics, University of Guadalajara, Guadalajara, Jalisco, Mexico.
Tannia Isabel Campos-BayardoDepartment of Physiology, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco, Mexico.
Daniel Román-RojasDepartment of Physiology, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco, Mexico.
Luis Francisco Gómez-HermosilloDepartment of Surgery, Civil Hospital of Guadalajara "Dr. Juan I Menchaca", Guadalajara, Jalisco, Mexico.
Jorge Casillas-MorenoDepartment of Surgery, Civil Hospital of Guadalajara "Dr. Juan I Menchaca", Guadalajara, Jalisco, Mexico.
Raquel EchavarríaSecihti- University Center of Los Altos, University of Guadalajara, Tepatitlán de Morelos, Jalisco, Mexico.
Elodia Nataly Díaz-de la CruzDepartment of Physiology, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco, Mexico.
Sylvia Totsuka-SuttoDepartment of Physiology, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco, Mexico.
Alejandra Guillermina Miranda-DíazDepartment of Physiology, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Chronic kidney disease (CKD) may improve with appropriate management and close monitoring to prevent the risk of progression to end-stage kidney disease (ESKD). The present study aimed to determine oxidative damage and DNA repair in early kidney disease in patients with and without type 2 diabetes (T2D). Methods: Using ELISA, serum levels of the oxidative DNA damage marker (8OHdG) and the DNA repair marker (hOGG1) were determined in 100 patients with T2D and 88 without T2D in stages 1, 2, and 3 of CKD. Results: The mean number of years of T2D in patients in stages 1, 2, and 3 was 13.93 ± 2.09 years. Significantly increased levels of the 8-OHdG marker were found in stage 3 CKD patients with T2D, 4.96(4.17-5.08) ng/mL

Indexed as

chronic kidney diseasediabetes mellitusearly kidney diseaseoxidative damage to DNArepair of oxidative damage to DNA

Identifiers

PMID41040429
PMCPMC12483919

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