Evidence map›Paper›PMID 41040404›Full record

ArticlebioRxiv : the preprint server for biology2025

Differentiation stage-specific use of cap-independent and cap-dependent translation initiation in hematopoiesis.

Michael C Mazzola, Ting Zhao, Anna Kiem, Trine A Kristiansen, Karin Gustafsson, Lai Ping Wong, Emily Scott-Solomon, Marissa D Fahlberg, Sarah Forward, Emane Rose Assita and 15 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Degrons: defining the rules of protein degradation.Nature reviews. Molecular cell biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Michael C MazzolaCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Ting ZhaoCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Anna KiemCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Trine A KristiansenCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Karin GustafssonCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Lai Ping WongDepartment of Molecular Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Emily Scott-SolomonHarvard Stem Cell Institute, 7 Divinity Avenue, Cambridge, MA 02138, USA.
Marissa D FahlbergLASE Innovation Inc., 335 Bear Hill Road, Waltham, MA 02451, USA.
Sarah ForwardLASE Innovation Inc., 335 Bear Hill Road, Waltham, MA 02451, USA.
Emane Rose AssitaLASE Innovation Inc., 335 Bear Hill Road, Waltham, MA 02451, USA.
Giulia SchiroliCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Maris HandleyCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Youmna KfouryCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Tsuyoshi FukushimaCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Samuel KeyesCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Azeem ShardaCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Jelena MilosevicCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Hiroki KatoCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Pavel IvanovDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.
David B SykesCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Sheldon J J KwokLASE Innovation Inc., 335 Bear Hill Road, Waltham, MA 02451, USA.
Ruslan I SadreyevDepartment of Molecular Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Vijay G SankaranHarvard Stem Cell Institute, 7 Divinity Avenue, Cambridge, MA 02138, USA.
Ya-Chieh HsuHarvard Stem Cell Institute, 7 Divinity Avenue, Cambridge, MA 02138, USA.
David T ScaddenCenter for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.

Funding

Transcriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI David T Scadden · 2017 to 2026
$24.6M
Molecular, Cellular, & Developmental Dynamics PhD ProgramT32GM007226 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI VAN VACTOR, DAVID L. · 1985 to 2021
$14.4M
Training in Pharmacological SciencesT32GM132089 · NIGMS · HARVARD MEDICAL SCHOOL · PI DAVID E. GOLAN, Timothy J Mitchison · 2019 to 2026
$3.7M
Cap-Dependency in Hematopoietic Stem and Progenitor Cell TranslationF31HL158020 · NHLBI · HARVARD MEDICAL SCHOOL · PI MAZZOLA, MICHAEL · 2021 to 2023
$81k
NHLBI NIH HHS F31 HL158020NHLBI NIH HHS P01 HL131477NIGMS NIH HHS T32 GM007226NIGMS NIH HHS T32 GM132089
6 · The paper itself

Abstract

Cell stress can increase the use of m

Identifiers

PMID41040404
PMCPMC12485689

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.