Evidence map›Paper›PMID 41040396›Full record

ArticlebioRxiv : the preprint server for biology2025

Muscular dystrophy-associated lamin variants disrupt cellular organization through a nucleolar-ribosomal axis controlling cytoplasmic macromolecular crowding.

Xiangyi Ding, Sweta Kumari, Ellen Gregory, Daniel A Starr, G W Gant Luxton

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Xiangyi DingDepartment of Molecular and Cellular Biology, University of California, Davis; Davis, CA, USA.ORCID 0009-0009-4831-1274
Sweta KumariDepartment of Molecular and Cellular Biology, University of California, Davis; Davis, CA, USA.
Ellen GregoryDepartment of Molecular and Cellular Biology, University of California, Davis; Davis, CA, USA.ORCID 0000-0002-2228-8258
Daniel A StarrDepartment of Molecular and Cellular Biology, University of California, Davis; Davis, CA, USA.ORCID 0000-0001-7339-6606
G W Gant LuxtonDepartment of Molecular and Cellular Biology, University of California, Davis; Davis, CA, USA.ORCID 0000-0002-6180-8906

Funding

Mechanisms of Nuclear MigrationR35GM134859 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DANIEL A STARR · 2020 to 2026
$2.8M
NIGMS NIH HHS R35 GM134859
6 · The paper itself

Abstract

Emery-Dreifuss muscular dystrophy (EDMD) arises from mutations in nuclear lamins or emerin. Current pathological models emphasize defects in nuclear mechanics and transcription regulation. Yet these models do not fully explain the complexity of EDMD or other laminopathies. Here, we uncover an emerging pathway linking nuclear lamina defects to the reorganization of cytoplasmic biophysics, revealing how nuclear dysfunction cascades throughout the cell. Using

Identifiers

PMID41040396
PMCPMC12485773

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.