Evidence map›Paper›PMID 41040395›Full record

ArticlebioRxiv : the preprint server for biology2025

The CAGE complex: a hollow, megadalton, protein assembly in prokaryotic and eukaryotic microbes.

Caitlyn L McCafferty, Gabriel Hoogerbrugge, Ophelia Papoulas, Evan A Schwartz, Simone Ritchey, David W Taylor, Axel F Brilot, Edward M Marcotte

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Caitlyn L McCaffertyDepartment of Molecular Biosciences, The University of Texas at Austin Austin, TX 78712, USA.ORCID 0000-0002-0872-4527
Gabriel HoogerbruggeDepartment of Molecular Biosciences, The University of Texas at Austin Austin, TX 78712, USA.ORCID 0000-0001-7617-3168
Ophelia PapoulasDepartment of Molecular Biosciences, The University of Texas at Austin Austin, TX 78712, USA.ORCID 0000-0002-6370-0616
Evan A SchwartzSauer Structural Biology Laboratory, The University of Texas at Austin Austin, TX 78712, USA.ORCID 0000-0002-7468-9010
Simone RitcheyDepartment of Molecular Biosciences, The University of Texas at Austin Austin, TX 78712, USA.ORCID 0009-0008-8329-4687
David W TaylorDepartment of Molecular Biosciences, The University of Texas at Austin Austin, TX 78712, USA.ORCID 0000-0002-6198-1194
Axel F BrilotSauer Structural Biology Laboratory, The University of Texas at Austin Austin, TX 78712, USA.ORCID 0000-0001-8548-4224
Edward M MarcotteDepartment of Molecular Biosciences, The University of Texas at Austin Austin, TX 78712, USA.ORCID 0000-0001-8808-180X

Funding

Mapping the CPLANE interactome, an extensive protein interaction network underlying human ciliopathiesR01HD085901 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI EDWARD M MARCOTTE, John B Wallingford · 2016 to 2026
$6.2M
Proteomics and model organism humanization to decode human geneticsR35GM122480 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI EDWARD M MARCOTTE · 2017 to 2026
$5.4M
Imaging macromolecular machines in gene regulationR35GM138348 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI TAYLOR, DAVID W · 2020 to 2024
$1.9M
NICHD NIH HHS R01 HD085901NIGMS NIH HHS R35 GM122480NIGMS NIH HHS R35 GM138348
6 · The paper itself

Abstract

We describe the identification and three-dimensional (3D) structure determination of an approx. 1 MDa, hollow, elliptical protein cage discovered while surveying proteins isolated from the ciliary matrix of the ciliate

Indexed as

ciliacryo-electron microscopyDictyosteliumevolutionmass spectrometryprotein complexprotein structureTetrahymena

Identifiers

PMID41040395
PMCPMC12485934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.