Evidence map›Paper›PMID 41040388›Full record

ArticlebioRxiv : the preprint server for biology2025

Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin.

Agnisrota Mazumder, John Cooper, Can Goksal, Jasbeer S Khanduja, Richard I Joh, Johannes J Groos, Rosario Y J Brockhausen, Junko Kanoh, Mo Motamedi, Ilya J Finkelstein and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Agnisrota MazumderInstitute for Genetics, Faculty of Biology and Chemistry, Justus Liebig University Giessen, Germany.ORCID 0009-0000-1988-8650
John CooperDept. Molecular Biosciences, The University of Texas-Austin, USA.ORCID 0000-0002-4867-0367
Can GoksalDepartment of Microbiology and Immunology, George Williams Hooper Foundation, University of California San Francisco, USA.ORCID 0009-0000-9034-7785
Jasbeer S KhandujaMassachusetts General Hospital Krantz Family Center for Cancer Research and Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA.ORCID 0009-0000-6415-367X
Richard I JohDepartment of Physics, Virginia Commonwealth University, Richmond, VA 23220, USA.ORCID 0000-0003-0583-8032
Johannes J GroosInstitute for Genetics, Faculty of Biology and Chemistry, Justus Liebig University Giessen, Germany.ORCID 0009-0007-2294-9224
Rosario Y J BrockhausenInstitute for Genetics, Faculty of Biology and Chemistry, Justus Liebig University Giessen, Germany.
Junko KanohDept. Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Japan.ORCID 0000-0002-8889-033X
Mo MotamediMassachusetts General Hospital Krantz Family Center for Cancer Research and Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA.ORCID 0000-0002-2031-6155
Ilya J FinkelsteinDept. Molecular Biosciences, The University of Texas-Austin, USA.ORCID 0000-0002-9371-2431
Bassem Al-SadyDepartment of Microbiology and Immunology, George Williams Hooper Foundation, University of California San Francisco, USA.ORCID 0000-0002-8996-7941
Sigurd BraunInstitute for Genetics, Faculty of Biology and Chemistry, Justus Liebig University Giessen, Germany.ORCID 0000-0001-6399-8574

Funding

Tracking how molecular machines propagate epigenetic information in time and spaceR35GM141888 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AL-SADY, BASSEM · 2021 to 2025
$2.3M
Molecular mechanism of heterochromatin formationR01GM155466 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI Mo Motamedi · 2025 to 2026
$814k
NIGMS NIH HHS R01 GM155466NIGMS NIH HHS R35 GM141888
6 · The paper itself

Abstract

Subtelomeres are imperfect repeats adjacent to telomeres that are repressed by heterochromatin. Although essential for genome integrity, their repetitive nature has thwarted dissection of local heterochromatin assembly and maintenance mechanisms. Here, we engineered

Indexed as

epigenetic variegationH3K9 methylationnucleation and spreadingSchizosaccharomyces pombeSubtelomeric heterochromatin

Identifiers

PMID41040388
PMCPMC12485837

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.